Lustri Bruna C, Sperandio Vanessa, Moreira Cristiano G
Department of Biological Sciences, São Paulo State University, UNESP, Araraquara, SP, Brazil.
Departments of Microbiology and Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Infect Immun. 2017 Nov 17;85(12). doi: 10.1128/IAI.00476-17. Print 2017 Dec.
Intestinal bacteria employ microbial metabolites from the microbiota and chemical signaling during cell-to-cell communication to regulate several cellular functions. Pathogenic bacteria are extremely efficient in orchestrating their response to these signals through complex signaling transduction systems. Precise coordination and interpretation of these multiple chemical cues is important within the gastrointestinal (GI) tract. Enteric foodborne pathogens, such as enterohemorrhagic (EHEC) and serovar Typhimurium, or the surrogate murine infection model for EHEC, , are all examples of microorganisms that modulate the expression of their virulence repertoire in response to signals from the microbiota or the host, such as autoinducer-3 (AI-3), epinephrine (Epi), and norepinephrine (NE). The QseBC and QseEF two-component systems, shared by these pathogens, are involved in sensing these signals. We review how these signaling systems sense and relay these signals to drive bacterial gene expression; specifically, to modulate virulence. We also review how bacteria chat via chemical signals integrated with metabolite recognition and utilization to promote successful associations among enteric pathogens, the microbiota, and the host.
肠道细菌在细胞间通讯过程中利用微生物群产生的微生物代谢产物和化学信号来调节多种细胞功能。病原菌通过复杂的信号转导系统极其有效地协调它们对这些信号的反应。在胃肠道（GI）内，对这些多种化学信号的精确协调和解读很重要。肠道食源性病原体，如肠出血性大肠杆菌（EHEC）和鼠伤寒血清型，或EHEC的替代小鼠感染模型，都是根据来自微生物群或宿主的信号（如自诱导物-3（AI-3）、肾上腺素（Epi）和去甲肾上腺素（NE））来调节其毒力库表达的微生物实例。这些病原体共有的QseBC和QseEF双组分系统参与感知这些信号。我们综述了这些信号系统如何感知并传递这些信号以驱动细菌基因表达；特别是调节毒力。我们还综述了细菌如何通过与代谢物识别和利用整合的化学信号进行交流，以促进肠道病原体、微生物群和宿主之间的成功关联。
