Kendall Melissa M, Sperandio Vanessa
Department of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, USA
mBio. 2016 Mar 1;7(2):e01748. doi: 10.1128/mBio.01748-15.
Chemical signaling between cells is an effective way to coordinate behavior within a community. Although cell-to-cell signaling has mostly been studied in single species, it is now appreciated that the sensing of chemical signals across kingdoms can be an important regulator of nutrient acquisition, virulence, and host defense. In this review, we focus on the role of interkingdom signaling in the interactions that occur between bacterial pathogens and their mammalian hosts. We discuss the quorum-sensing (QS) systems and other mechanisms used by these bacteria to sense, respond to, and modulate host signals that include hormones, immune factors, and nutrients. We also describe cross talk between these signaling pathways and strategies used by the host to interfere with bacterial signaling, highlighting the complex bidirectional signaling networks that are established across kingdoms.
细胞间的化学信号传导是协调群体内行为的有效方式。尽管细胞间信号传导大多是在单一物种中进行研究的，但现在人们认识到跨生物界对化学信号的感知可能是营养获取、毒力和宿主防御的重要调节因子。在这篇综述中，我们重点关注跨界信号传导在细菌病原体与其哺乳动物宿主之间相互作用中的作用。我们讨论了这些细菌用于感知、响应和调节宿主信号（包括激素、免疫因子和营养物质）的群体感应（QS）系统及其他机制。我们还描述了这些信号通路之间的相互作用以及宿主用于干扰细菌信号传导的策略，突出了跨生物界建立的复杂双向信号网络。
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