García-Ceca Javier, Alfaro David, Montero-Herradón Sara, Tobajas Esther, Muñoz Juan José, Zapata Agustín G
Department of Cell Biology, Faculty of Biology, Complutense University , Madrid , Spain.
Cytometry and Fluorescence Microscopy Center, Complutense University , Madrid , Spain.
Front Immunol. 2015 Jun 26;6:333. doi: 10.3389/fimmu.2015.00333. eCollection 2015.
Numerous studies emphasize the relevance of thymocyte-thymic epithelial cell (TECs) interactions for the functional maturation of intrathymic T lymphocytes. The tyrosine kinase receptors, Ephs (erythropoietin-producing hepatocyte kinases) and their ligands, ephrins (Eph receptor interaction proteins), are molecules known to be involved in the regulation of numerous biological systems in which cell-to-cell interactions are particularly relevant. In the last years, we and other authors have demonstrated the importance of these molecules in the thymic functions and the T-cell development. In the present report, we review data on the effects of Ephs and ephrins in the functional maturation of both thymic epithelial microenvironment and thymocyte maturation as well as on their role in the lymphoid progenitor recruitment into the thymus.
众多研究强调胸腺细胞与胸腺上皮细胞（TECs）相互作用对于胸腺内T淋巴细胞功能成熟的相关性。酪氨酸激酶受体Ephs（促红细胞生成素产生性肝细胞激酶）及其配体ephrins（Eph受体相互作用蛋白）是已知参与众多生物系统调节的分子，在这些生物系统中细胞间相互作用尤为重要。在过去几年中，我们和其他作者已经证明了这些分子在胸腺功能和T细胞发育中的重要性。在本报告中，我们综述了关于Ephs和ephrins在胸腺上皮微环境功能成熟以及胸腺细胞成熟中的作用的数据，以及它们在淋巴祖细胞募集到胸腺中的作用。
