Mitani K, Kurosawa H, Suzuki A, Hayashi Y, Hanada R, Yamamoto K, Komatsu A, Kobayashi N, Nakagome Y, Yamada M
Jpn J Cancer Res. 1986 Nov;77(11):1062-5.
N-myc is a member of the myc oncogene family and has been thought to be specific to neurogenic cells, since it is amplified in some neuroblastomas, retinoblastomas and small-cell lung carcinomas with endocrine properties. Hybridization analyses of DNAs isolated from surgically removed tumors revealed that N-myc was amplified about 6-fold in one of the three embryonic rhabdomyosarcomas examined. The rhabdomyosarcoma containing the amplified N-myc had metastasized into bone marrow, which is preferentially involved in the metastasis of neuroblastomas but is usually not involved in the case of rhabdomyosarcomas. Since rhabdomyoblasts are derived from mesenchyme, this indicates that N-myc gene amplification is not restricted to neurogenic tumors.
N-myc是myc癌基因家族的成员，由于它在一些具有内分泌特性的神经母细胞瘤、视网膜母细胞瘤和小细胞肺癌中发生扩增，一直被认为对神经源性细胞具有特异性。对手术切除肿瘤中分离出的DNA进行杂交分析发现，在所检测的3例胚胎性横纹肌肉瘤中，有1例的N-myc扩增了约6倍。含有扩增N-myc的横纹肌肉瘤已经转移至骨髓，骨髓是神经母细胞瘤转移时优先累及的部位，但横纹肌肉瘤通常不会累及。由于成肌细胞来源于间充质，这表明N-myc基因扩增并不局限于神经源性肿瘤。
