Qi Yiqiang, Liu Xiaohui, Li Jun, Yao Huiqian, Yuan Shuanghu
School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong Cancer Hospital affiliated to Shandong University, Jinan, Shandong, China.
Oncotarget. 2017 Aug 4;8(36):60581-60588. doi: 10.18632/oncotarget.19943. eCollection 2017 Sep 1.
Tumor glucose metabolism and amino acid metabolism are usually enhanced, F-FDG for tumor glucose metabolism PET imaging has been clinically well known, but tumor amino acid metabolism PET imaging is not clinically familiar. Radiolabeled amino acids (AAs) are an important class of PET/CT tracers that target the upregulated amino acid transporters to show elevated amino acid metabolism in tumor cells. Radiolabeled amino acids were observed to have high uptake in tumor cells but low in normal tissues and inflammatory tissues. The radionuclides used in labeling amino acids include O, N, C, I, F and Ga, among which the most commonly used is F [1]. Available data support the use of certain F-labeled AAs for PET/CT imaging of gliomas, neuroendocrine tumors, prostate cancer and breast cancer [2, 3]. With the progress of the method of F labeling AAs [4-6], F-labeled AAs are well established for tumor PET/CT imaging. This review focuses on the current status of key clinical applications of 18F-labeled AAs in tumor PET/CT imaging.
肿瘤葡萄糖代谢和氨基酸代谢通常会增强，18F-FDG用于肿瘤葡萄糖代谢的PET成像在临床上已广为人知，但肿瘤氨基酸代谢的PET成像在临床上并不常见。放射性标记氨基酸（AAs）是一类重要的PET/CT示踪剂，其靶向上调的氨基酸转运体以显示肿瘤细胞中升高的氨基酸代谢。观察到放射性标记氨基酸在肿瘤细胞中摄取高，但在正常组织和炎症组织中摄取低。用于标记氨基酸的放射性核素包括O、N、C、I、F和Ga，其中最常用的是F[1]。现有数据支持使用某些F标记的氨基酸进行胶质瘤、神经内分泌肿瘤、前列腺癌和乳腺癌的PET/CT成像[2,3]。随着F标记氨基酸方法的进展[4-6]，F标记氨基酸在肿瘤PET/CT成像中已得到充分确立。本综述重点关注18F标记氨基酸在肿瘤PET/CT成像关键临床应用的现状。
