The Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, 311300, Zhejiang, China.
Research Center of Diagnosis and Treatment Technology for Hepatocellular Carcinoma of Zhejiang Province, Hangzhou, 311300, Zhejiang, China.
Apoptosis. 2023 Oct;28(9-10):1304-1314. doi: 10.1007/s10495-023-01875-9. Epub 2023 Jul 31.
Amino acids (AAs) are crucial molecules for the synthesis of mammalian proteins as well as a source of energy and redox equilibrium maintenance. The development of tumors also requires AAs as nutrients. Increased AAs metabolism is frequently seen in tumor cells to produce enough biomass, energy, and reduction agents. However, increased AA demand may result in auxotrophy in some cancer cells, highlighting the vulnerabilities of cancers and exposing the AA metabolism as a potential target for cancer therapy. The dynamic balance of cell survival and death is required for cellular homeostasis, growth, and development. Malignant cells manage to avoid cell death through a range of mechanisms, such as developing an addiction to amino acids through metabolic adaptation. In order to offer some guidance for AA-targeted cancer therapy, we have outlined the function of AA metabolism in tumor progression, the modalities of cell death, and the regulation of AA metabolism on tumor cell death in this review.
氨基酸（AAs）是合成哺乳动物蛋白质的关键分子，也是能量和氧化还原平衡维持的来源。肿瘤的发展也需要氨基酸作为营养物质。肿瘤细胞中经常会出现氨基酸代谢增加，以产生足够的生物量、能量和还原剂。然而，增加的 AA 需求可能导致某些癌细胞出现营养缺陷，突出了癌症的脆弱性，并将 AA 代谢暴露为癌症治疗的潜在靶点。细胞存活和死亡的动态平衡是细胞内稳态、生长和发育所必需的。恶性细胞通过一系列机制来避免细胞死亡，例如通过代谢适应对氨基酸产生依赖。为了为 AA 靶向癌症治疗提供一些指导，我们在这篇综述中概述了 AA 代谢在肿瘤进展、细胞死亡方式以及 AA 代谢对肿瘤细胞死亡的调节中的作用。
