Kurzynski T A, Boehm D M, Rott-Petri J A, Schell R F, Allison P E
State Laboratory of Hygiene, University of Wisconsin, Madison 53706.
Antimicrob Agents Chemother. 1988 Jan;32(1):137-40. doi: 10.1128/AAC.32.1.137.
MICs for 90% (MIC90s) of 75 Bordetella pertussis strains for amoxicillin, erythromycin, rifampin, and sulfamethoxazole-trimethoprim were 1, less than or equal to 0.12, 1, and 4 micrograms/ml, respectively. Susceptibility rates were all greater than or equal to 93%. Only 17% of the strains were susceptible to tetracycline. The MIC90s of ciprofloxacin, enoxacin, norfloxacin, ofloxacin, and roxithromycin were less than or equal to 0.06, 0.5, 0.25, 0.12, and 0.5 micrograms/ml, respectively. For B. parapertussis, the MIC90s were 16-fold higher with amoxicillin and rifampin and 2- to 4-fold higher with the fluoroquinolones and roxithromycin.
75株百日咳博德特氏菌对阿莫西林、红霉素、利福平及磺胺甲恶唑-甲氧苄啶的90%抑菌浓度(MIC90s)分别为1、小于或等于0.12、1及4微克/毫升。药敏率均大于或等于93%。仅17%的菌株对四环素敏感。环丙沙星、依诺沙星、诺氟沙星、氧氟沙星及罗红霉素的MIC90s分别小于或等于0.06、0.5、0.25、0.12及0.5微克/毫升。对于副百日咳博德特氏菌,阿莫西林和利福平的MIC90s高16倍,氟喹诺酮类和罗红霉素的MIC90s高2至4倍。