Hoppe J E, Simon C G
University Children's Hospital, Tübingen, Federal Republic of Germany.
Antimicrob Agents Chemother. 1990 Nov;34(11):2287-8. doi: 10.1128/AAC.34.11.2287.
The in vitro susceptibilities of Bordetella pertussis and Bordetella parapertussis to seven fluoroquinolones were assessed by the agar dilution method. Ciprofloxacin and temafloxacin were the most active compounds (MIC for 90% of isolates tested [MIC90], 0.06 microgram/ml), while enoxacin and pefloxacin were the least active (MIC90, 0.5 microgram/ml). Fleroxacin, lomefloxacin, and ofloxacin showed intermediate activities (MIC90s, 0.125 to 0.25 microgram/ml). These results suggest a possible role for the fluoroquinolones in the treatment of pertussis, at least in adult patients.
采用琼脂稀释法评估了百日咳博德特氏菌和副百日咳博德特氏菌对七种氟喹诺酮类药物的体外敏感性。环丙沙星和替马沙星是活性最强的化合物(对90%受试分离株的最低抑菌浓度[MIC90]为0.06微克/毫升),而依诺沙星和培氟沙星活性最低(MIC90为0.5微克/毫升)。氟罗沙星、洛美沙星和氧氟沙星表现出中等活性(MIC90为0.125至0.25微克/毫升)。这些结果表明氟喹诺酮类药物在百日咳治疗中可能有作用,至少对成年患者是这样。