Castro Juan M, García-Espinosa Victoria, Zinoveev Agustina, Marin Mariana, Severi Cecilia, Chiesa Pedro, Bia Daniel, Zócalo Yanina
Departamento de Fisiología, Facultad de Medicina, Centro Universitario de Investigación, Innovación y Diagnóstico Arterial, Universidad de la República, General Flores 2125, 11800 Montevideo, Uruguay.
Departamento de Medicina Preventiva y Social, Instituto de Higiene, Facultad de Medicina, Universidad de la República, Alfredo Navarro 3051, 11600 Montevideo, Uruguay.
J Cardiovasc Dev Dis. 2019 Sep 6;6(3):33. doi: 10.3390/jcdd6030033.
An association between nutritional characteristics in theearlylife stages and the state of the cardiovascular (CV) system in early childhood itself and/or at the beginning of adulthood has been postulated. It is still controversial whether changes in weight, height and/or body mass index (BMI) during childhood or adolescence are independently associated with hemodynamics and/or arterial properties in early childhood and adulthood.
First, to evaluate and compare the strength of association between CVproperties (at 6 and 18 years (y)) and (a) anthropometric data at specific growth stages (e.g., birth, 6 y, 18 y) and (b) anthropometric changes during early (0-2 y), intermediate (0-6 y), late (6-18 y) and global (0-18 y) growth. Second, to determine whether the associations between CVproperties and growth-related body changes depend on size at birth and/or at the time of CVstudy. Third, to analyze the capacity of growth-related body size changes to explain hemodynamic and arterial properties in early childhood and adulthood before and after adjusting for exposure to CV risk factors. Anthropometric, hemodynamic (central, peripheral) and arterial parameters (structural, functional; elastic, transitional and muscular arteries) were assessed in two cohorts (children, = 682; adolescents, = 340). Data wereobtained and analyzed following identical protocols.
Body-size changes in infancy (0-2 y) and childhood (0-6 y) showed similar strength of association with CV properties at 6 y. Conversely, 0-6, 6-18 or 0-18 ychanges were not associated with CV parameters at 18 y. The association between CV properties at 6 yand body-size changes during growth showed: equal or greater strength than the observed for body-size at birth, and lower strength compared to that obtained for current z-BMI. Conversely, only z-BMI at 18 y showed associations with CV z-scores at 18 y. Body size at birth showed almost no association with CVproperties at 6 or 18 y.
current z-BMI showed the greatest capacity to explain variations in CV properties at 6 and 18 y. Variations in some CV parameters were mainly explained by growth-related anthropometric changes and/or by their interaction with current z-BMI. Body size at birth showed almost no association with arterial properties at 6 or 18 y.
有人提出生命早期阶段的营养特征与儿童早期本身和/或成年初期心血管（CV）系统的状态之间存在关联。儿童期或青春期体重、身高和/或体重指数（BMI）的变化是否与儿童期和成年期的血流动力学和/或动脉特性独立相关，目前仍存在争议。
第一，评估并比较CV特性（6岁和18岁时）与（a）特定生长阶段（如出生时、6岁、18岁）的人体测量数据以及（b）早期（0 - 2岁）、中期（0 - 6岁）、晚期（6 - 18岁）和总体（0 - 18岁）生长期间人体测量变化之间的关联强度。第二，确定CV特性与生长相关身体变化之间的关联是否取决于出生时和/或CV研究时的体型。第三，分析生长相关身体大小变化在调整CV危险因素暴露前后解释儿童期和成年期血流动力学和动脉特性的能力。在两个队列（儿童，n = 682；青少年，n = 340）中评估了人体测量、血流动力学（中心、外周）和动脉参数（结构、功能；弹性、过渡性和肌性动脉）。按照相同方案获取并分析数据。
婴儿期（0 - 2岁）和儿童期（0 - 6岁）的身体大小变化与6岁时的CV特性显示出相似的关联强度。相反，0 - 6岁、6 - 18岁或0 - 18岁的变化与18岁时的CV参数无关。6岁时的CV特性与生长期间身体大小变化之间的关联显示：强度等于或大于出生时身体大小的关联强度，且低于当前z - BMI的关联强度。相反，只有18岁时的z - BMI与18岁时的CV z分数显示出关联。出生时的身体大小与6岁或18岁时的CV特性几乎没有关联。
当前z - BMI显示出在解释6岁和18岁时CV特性变化方面的最大能力。一些CV参数的变化主要由生长相关的人体测量变化和/或它们与当前z - BMI的相互作用来解释。出生时的身体大小与6岁或18岁时的动脉特性几乎没有关联。
