局部动脉僵硬度的参考值。B部分：股动脉。
Reference values for local arterial stiffness. Part B: femoral artery.
作者信息
Bossuyt Jelle, Engelen Lian, Ferreira Isabel, Stehouwer Coen D, Boutouyrie Pierre, Laurent Stéphane, Segers Patrick, Reesink Koen, Van Bortel Luc M
机构信息
aHeymans Institute of Pharmacology, Research Unit of Clinical Pharmacology, Ghent University, Ghent, Belgium bDepartment of Internal Medicine cCARIM School for Cardiovascular Diseases, Maastricht University Medical Centre, Maastricht dTop Institute Food and Nutrition, Wageningen eDepartment of Clinical Epidemiology and Medical Technology Assessment (KEMTA), Maastricht University Medical Centre, Maastricht, the Netherlands fDepartment of Pharmacology and INSERM U970, Hôpital Européen Georges Pompidou, Paris, France gInstitute biomedical Technology (IBiTech), iMinds Medical IT, Ghent University, Ghent, Belgium hDepartment of Biomedical Engineering, Maastricht University Medical Centre, Maastricht, the Netherlands. *A complete author list is included in the Appendix (Table A1).
出版信息
J Hypertens. 2015 Oct;33(10):1997-2009. doi: 10.1097/HJH.0000000000000655.
OBJECTIVE
Carotid-femoral pulse wave velocity (PWV) is considered the gold standard measure of arterial stiffness, representing mainly aortic stiffness. As compared with the elastic carotid and aorta, the more muscular femoral artery may be differently associated with cardiovascular risk factors (CV-RFs), or, as shown in a recent study, provide additional predictive information beyond carotid-femoral PWV. Still, clinical application is hampered by the absence of reference values. Therefore, our aim was to establish age and sex-specific reference values for femoral stiffness in healthy individuals and to investigate the associations with CV-RFs.
METHODS
Femoral artery distensibility coefficient, the inverse of stiffness, was calculated as the ratio of relative diastolic-systolic distension (obtained from ultrasound echo-tracking) and pulse pressure among 5069 individuals (49.5% men, age range: 15-87 years). Individuals without cardiovascular disease (CVD), CV-RFs and medication use (n = 1489; 43% men) constituted a healthy subpopulation used to establish sex-specific equations for percentiles of femoral artery distensibility coefficient across age.
RESULTS
In the total population, femoral artery distensibility coefficient Z-scores were independently associated with BMI, mean arterial pressure (MAP) and total to high-density lipoprotein (HDL) cholesterol ratio. Standardized βs, in men and women, respectively, were -0.18 [95% confidence interval (95% CI) -0.23 to -0.13] and -0.19 (-0.23 to -0.14) for BMI; -0.13 (-0.18 to -0.08) and -0.05 (-0.10 to -0.01) for MAP; and -0.07 (-0.11 to -0.02) and -0.16 (-0.20 to -0.11) for total-to-HDL cholesterol ratio.
CONCLUSION
In young and middle-aged men and women, normal femoral artery stiffness does not change substantially with age up to the sixth decade. CV-RFs related to metabolic disease are associated with femoral artery stiffness.
目的
颈股脉搏波速度（PWV）被视为动脉僵硬度的金标准测量指标，主要代表主动脉僵硬度。与弹性的颈动脉和主动脉相比，肌肉更丰富的股动脉可能与心血管危险因素（CV-RFs）存在不同的关联，或者如最近一项研究所示，可提供超出颈股PWV的额外预测信息。然而，由于缺乏参考值，其临床应用受到阻碍。因此，我们的目的是建立健康个体股动脉僵硬度的年龄和性别特异性参考值，并研究其与CV-RFs的关联。
方法
在5069名个体（49.5%为男性，年龄范围：15 - 87岁）中，通过超声回声跟踪获得相对舒张期 - 收缩期扩张度，并计算其与脉压的比值，以此来计算股动脉扩张系数（僵硬度的倒数）。无心血管疾病（CVD）、CV-RFs且未使用药物的个体（n = 1489；43%为男性）构成一个健康亚组，用于建立不同年龄阶段股动脉扩张系数百分位数的性别特异性方程。
结果
在总体人群中，股动脉扩张系数Z评分与体重指数（BMI）、平均动脉压（MAP）以及总胆固醇与高密度脂蛋白（HDL）胆固醇比值独立相关。在男性和女性中，BMI的标准化β值分别为 -0.18 [95%置信区间（95%CI） -0.23至 -0.13] 和 -0.19（-0.23至 -0.14）；MAP的标准化β值分别为 -0.13（-0.18至 -0.08）和 -0.05（-0.10至 -0.01）；总胆固醇与HDL胆固醇比值的标准化β值分别为 -0.07（-0.11至 -0.02）和 -0.16（-0.
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