Adamcová K, Kolátorová L, Chlupáčová T, Šimková M, Jandíková H, Pařízek A, Stárka L, Dušková M
Department of Obstetrics and Gynecology of the First Faculty of Medicine and General Teaching Hospital, Prague, Czech Republic, Institute of Endocrinology, Prague, Czech Republic.
Physiol Res. 2017 Sep 26;66(Suppl 3):S375-S386. doi: 10.33549/physiolres.933728.
Smoking during pregnancy presents health risks for both the mother and her child. In this study we followed changes in the production of steroid hormones in pregnant smokers. We focused on changes in steroidogenesis in the blood of mothers in their 37(th) week of pregnancy and in mixed cord blood from their newborns. The study included 88 healthy women with physiological pregnancies (17 active smokers and 71 non-smokers). We separately analyzed hormonal changes associated with smoking according to the sex of newborns. In women with male fetuses, we found higher levels of serum cortisone, dehydroepiandrosterone (DHEA), 7alpha-OH-DHEA, 17-OH pregnenolone, testosterone, and androstenedione in smokers at the 37(th) week compared to non-smokers. In women with female fetuses, we found lower serum levels of 7beta-OH-DHEA and higher androstenedione in smokers at the 37(th) week. We found significantly higher levels of testosterone in newborn males of smokers and higher levels of 7alpha-OH-DHEA in female newborns of smokers. Smoking during pregnancy induces changes in the production of steroids in both the mother and her child. These changes are different for different fetal sexes, with more pronounced changes in mothers carrying male newborns as well as in the newborn males themselves.
孕期吸烟对母亲和孩子的健康都会造成风险。在本研究中，我们追踪了孕期吸烟女性体内类固醇激素分泌的变化。我们重点关注了怀孕37周的母亲血液以及其新生儿脐血混合样本中类固醇生成的变化。该研究纳入了88名生理妊娠的健康女性（17名现吸烟者和71名非吸烟者）。我们根据新生儿性别分别分析了与吸烟相关的激素变化。在怀有男胎的女性中，我们发现与非吸烟者相比，吸烟者在怀孕37周时血清可的松、脱氢表雄酮（DHEA）、7α-羟基脱氢表雄酮、17-羟基孕烯醇酮、睾酮和雄烯二酮的水平更高。在怀有女胎的女性中，我们发现吸烟者在怀孕37周时血清7β-羟基脱氢表雄酮水平较低，而雄烯二酮水平较高。我们发现吸烟者的男婴体内睾酮水平显著更高，而吸烟者的女婴体内7α-羟基脱氢表雄酮水平更高。孕期吸烟会导致母亲和孩子体内类固醇分泌发生变化。这些变化因胎儿性别而异，怀有男婴的母亲以及男婴自身的变化更为明显。
