Ylikorkala O, Stenman U H, Halmesmäki E
Department of Obstetrics and Gynecology, University Central Hospital, Helsinki, Finland.
Obstet Gynecol. 1988 May;71(5):731-5.
We compared serum concentrations of total and free testosterone, androstenedione, dehydroepiandrosterone sulfate (DHEAS), and sex-hormone-binding globulin in 40 pregnant women exhibiting consistent alcohol abuse and in 20 abstinent pregnant controls. Sixteen drinkers gave birth to infants with fetal alcohol effects; the remaining 24 drinkers delivered healthy infants. Drinking patients with healthy infants had normal concentrations of total and free testosterone, sex-hormone-binding globulin, and DHEAS, but their levels of androstenedione increased between weeks 20-40 of pregnancy. Maternal drinking leading to fetal alcohol effects was accompanied by lowered concentrations of sex-hormone-binding globulin throughout pregnancy and by low total testosterone concentrations, although the latter difference reached statistical significance only at 16-20 weeks' gestation. In contrast, drinking leading to fetal damage was associated with higher free testosterone levels between weeks 16-20 of pregnancy and lowered concentrations of DHEAS between weeks 16-32 of gestation, whereas the androstenedione levels tended to be high throughout pregnancy. These changes in androgens can be explained in part by low sex-hormone-binding globulin concentrations, an insufficient supply of DHEAS by the adrenals, and reduced peripheral conversion of androstenedione to testosterone.
我们比较了40名持续酗酒的孕妇和20名戒酒的孕妇对照组血清中总睾酮、游离睾酮、雄烯二酮、硫酸脱氢表雄酮（DHEAS）和性激素结合球蛋白的浓度。16名饮酒者产下患有胎儿酒精影响的婴儿；其余24名饮酒者分娩出健康婴儿。产下健康婴儿的饮酒患者总睾酮、游离睾酮、性激素结合球蛋白和DHEAS浓度正常，但他们的雄烯二酮水平在妊娠20至40周之间升高。导致胎儿酒精影响的孕妇饮酒在整个孕期伴随着性激素结合球蛋白浓度降低以及总睾酮浓度降低，尽管后者的差异仅在妊娠16至20周时达到统计学显著性。相比之下，导致胎儿损伤的饮酒与妊娠16至20周之间较高的游离睾酮水平以及妊娠16至32周之间较低的DHEAS浓度相关，而雄烯二酮水平在整个孕期往往较高。雄激素的这些变化部分可以通过性激素结合球蛋白浓度低、肾上腺DHEAS供应不足以及雄烯二酮向睾酮的外周转化减少来解释。
