胡桃楸树皮中的细胞毒性木脂素。
Cytotoxic lignans from the barks of Juglans mandshurica.
作者信息
Zhang Xiao-Ning, Bai Ming, Cheng Zhuo-Yang, Yu Zhi-Guo, Huang Xiao-Xiao
机构信息
a Department of Pharmaceutical Analysis, School of Pharmacy , Shenyang Pharmaceutical University , Shenyang 110016 , China.
b Department of Antibiotics , Heilongjiang Province Food and Drug Inspection Testing Institute , Harbin 150080 , China.
出版信息
J Asian Nat Prod Res. 2018 May;20(5):494-499. doi: 10.1080/10286020.2017.1374256. Epub 2017 Sep 26.
Phytochemical investigation of the barks of Juglans mandshurica Maxim led to the isolation, purification, and identification of one new lignan named Juglansol A (1), along with nine known compounds (2-10). Their structures were determined by the results of UV, IR, CD, HRESIMS, 1D, and 2D NMR spectroscopic analysis. Compounds 1-10 were evaluated for their cytotoxicities against A549, HepG2, Hep3B, Bcap-37, and MCF-7 cell lines. The results showed that compound 2 possessed stronger cytotoxicities against the tested tumor cell lines compared with positive control 5-fluorouracil.
对胡桃楸（Juglans mandshurica Maxim）树皮进行植物化学研究，分离、纯化并鉴定出一种新的木脂素，命名为胡桃素A（1），以及9种已知化合物（2 - 10）。通过紫外光谱（UV）、红外光谱（IR）、圆二色光谱（CD）、高分辨电喷雾电离质谱（HRESIMS）、一维核磁共振（1D NMR）和二维核磁共振（2D NMR）光谱分析结果确定了它们的结构。对化合物1 - 10进行了抗A549、HepG2、Hep3B、Bcap - 37和MCF - 7细胞系的细胞毒性评价。结果表明，与阳性对照5 - 氟尿嘧啶相比，化合物2对测试的肿瘤细胞系具有更强的细胞毒性。
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