Yao Da-Lei, Zhang Chang-Hao, Li Ren, Luo Jie, Jin Mei, Piao Jin-Hua, Zheng Ming-Shan, Cui Jiong-Mo, Son Jong Keun, Li Gao
Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules, Ministry of Education, Yanbian University College of Pharmacy, Yanji 133002, China.
Department of Pharmacy, Yanbian University Hospital, Yanji 133000, China.
Chin J Nat Med. 2015 Apr;13(4):299-302. doi: 10.1016/S1875-5364(15)30018-2.
The present study was designed to isolate and characterize novel chemical constituents of the stem bark of Juglans mandshurica Maxim. (Juglandaceae). The chemical constituents were isolated and purified by various chromatographic techniques. The structures of the compounds were elucidated on the basis of spectral data (1D and 2D NMR, HR-ESI-MS, CD, UV, and IR) and by the comparisons of spectroscopic data with the reported values in the literatures. Two long chain polyunsaturated fatty acids (1 and 2) were obtained and identified as (S)-(8E,10E)-12-hydroxy-7-oxo-8,10-octadecadienoic acid (1) and (S)-(8E, 10E)-12-hydroxy-7-oxo-8,10-octadecadienoic acid methyl ester (2). To the best of our knowledge, this is the first report on the isolation and structural elucidation of the two new conjugated ketonic fatty acids from this genus.
本研究旨在分离并鉴定胡桃楸（胡桃科）茎皮中的新型化学成分。通过各种色谱技术对化学成分进行分离和纯化。基于光谱数据（一维和二维核磁共振、高分辨电喷雾电离质谱、圆二色光谱、紫外光谱和红外光谱）以及将光谱数据与文献报道值进行比较，阐明了化合物的结构。获得并鉴定了两种长链多不饱和脂肪酸（1和2），分别为(S)-(8E,10E)-12-羟基-7-氧代-8,10-十八碳二烯酸（1）和(S)-(8E,10E)-12-羟基-7-氧代-8,10-十八碳二烯酸甲酯（2）。据我们所知，这是首次从该属植物中分离并阐明这两种新型共轭酮脂肪酸结构的报道。
