Longnecker S M
Department of Pharmacy Services, Westmoreland Hospital, Greensburg, PA 15601.
Drug Intell Clin Pharm. 1988 Feb;22(2):99-106. doi: 10.1177/106002808802200201.
The somatostatins represent endogenous substances that serve a diversity of functions in the body. These activities are just beginning to be understood and could have major implications in the treatment of human disease. Their chief pharmacologic activities lie in the modification or modulation of protein hormone synthesis of the gastrointestinal system; a great many other systems may be involved as well. Since the discovery of the therapeutic potentials of naturally isolated somatostatins, attempts have been made to design newer analogs more conducive to practical use. Such an example is long-acting somatostatin analog octreotide. Literature has recently begun to appear describing the therapeutic activities of this and other similar compounds and the first steps to understanding their clinical pharmacology are being taken. Surprising activity has been found in the palliative treatment of a wide variety of formerly resistant gastrointestinal syndromes and endocrine tumors. These activities may have considerable future impact on the treatment of disease involving hormonal imbalance or inappropriate secretion.
生长抑素是体内发挥多种功能的内源性物质。这些作用才刚刚开始被了解，可能对人类疾病的治疗具有重要意义。它们的主要药理活性在于改变或调节胃肠系统的蛋白质激素合成；许多其他系统可能也会涉及。自从发现天然分离的生长抑素的治疗潜力以来，人们一直在尝试设计更有利于实际应用的新型类似物。长效生长抑素类似物奥曲肽就是这样一个例子。最近开始有文献描述这种及其他类似化合物的治疗活性，并且正在迈出了解它们临床药理学的第一步。在多种以前难治的胃肠综合征和内分泌肿瘤的姑息治疗中发现了惊人的活性。这些活性可能在未来对涉及激素失衡或分泌异常的疾病治疗产生重大影响。
