Faculty of Materials and Energy, Southwest University, Chongqing 400715, China.
Faculty of Materials and Energy, Southwest University, Chongqing 400715, China.
J Mech Behav Biomed Mater. 2018 Jan;77:225-233. doi: 10.1016/j.jmbbm.2017.09.014. Epub 2017 Sep 8.
In this study, a simple, cost-effective approach of polymeric foam replication was used to produce three-dimensionally macroporous titanium scaffolds with controllable porosities and mechanical properties. Two kinds of porous titanium scaffolds with different porosities (74.7% and 87.6%) and pore sizes (360µm and 750µm) were fabricated. Both of the scaffolds exhibit good compressive strength (24.5MPa and 13.5MPa) with a low elastic modulus (0.23GPa and 0.11GPa), approximating the mechanical properties of nature human cancellous bone (E = 10-50MPa, σ = 0.01-3.0GPa). Thereafter, the scaffolds were surface modified using plasma electrolyte oxidation (PEO) process to gain a bioactive porous titania ceramic coating. The SBF immersion test indicates PEO treated scaffolds show excellent bioactivity as the apatite rapidly nucleates and grows on the scaffold surface during 3-28 days. The results suggest that the highly porous titanium scaffolds with titania bioactive coatings are promising in cancellous bone replacement.
在这项研究中，采用了一种简单、经济有效的聚合物泡沫复制方法，制备出具有可控孔隙率和机械性能的三维大孔钛支架。制备了两种具有不同孔隙率（74.7%和 87.6%）和孔径（360µm 和 750µm）的多孔钛支架。两种支架均表现出良好的抗压强度（24.5MPa 和 13.5MPa）和较低的弹性模量（0.23GPa 和 0.11GPa），接近天然松质骨的力学性能（E = 10-50MPa，σ = 0.01-3.0GPa）。随后，通过等离子体电解氧化（PEO）工艺对支架进行表面改性，获得具有生物活性的多孔钛陶瓷涂层。SBF 浸泡试验表明，PEO 处理后的支架具有优异的生物活性，因为在 3-28 天内，支架表面迅速形成磷灰石。研究结果表明，具有钛生物活性涂层的高多孔钛支架在松质骨替代中具有广阔的应用前景。
