Dziaduszewska Magda, Zieliński Andrzej
Biomaterials Technology Division, Institute of Machines Technology and Materials, Faculty of Mechanical Engineering and Ship Building, Gdańsk University of Technology, 80-233 Gdańsk, Poland.
Materials (Basel). 2021 Feb 3;14(4):712. doi: 10.3390/ma14040712.
One of the biggest challenges in tissue engineering is the manufacturing of porous structures that are customized in size and shape and that mimic natural bone structure. Additive manufacturing is known as a sufficient method to produce 3D porous structures used as bone substitutes in large segmental bone defects. The literature indicates that the mechanical and biological properties of scaffolds highly depend on geometrical features of structure (pore size, pore shape, porosity), surface morphology, and chemistry. The objective of this review is to present the latest advances and trends in the development of titanium scaffolds concerning the relationships between applied materials, manufacturing methods, and interior architecture determined by porosity, pore shape, and size, and the mechanical, biological, chemical, and physical properties. Such a review is assumed to show the real achievements and, on the other side, shortages in so far research.
组织工程学面临的最大挑战之一是制造尺寸和形状定制且能模拟天然骨结构的多孔结构。增材制造是一种有效的方法，可用于生产用作大段骨缺损骨替代物的三维多孔结构。文献表明，支架的力学和生物学性能高度依赖于结构的几何特征（孔径、孔形状、孔隙率）、表面形态和化学性质。本综述的目的是介绍钛支架开发的最新进展和趋势，内容涉及所用材料、制造方法与由孔隙率、孔形状和尺寸决定的内部结构之间的关系，以及力学、生物学、化学和物理性能。这样的综述旨在展示目前研究取得的实际成果以及不足之处。
