Hira Tohru, Yanagihara Kurumi, Koga Toshiki, Takahashi Keisuke, Nagura Taizo, Uchino Hirokatsu, Hara Hiroshi
a Research Faculty of Agriculture, Laboratory of Nutritional Biochemistry , Hokkaido University , Sapporo , Japan.
b Graduate School of Agriculture , Hokkaido University , Sapporo , Japan.
Biosci Biotechnol Biochem. 2017 Nov;81(11):2186-2194. doi: 10.1080/09168451.2017.1373591. Epub 2017 Sep 27.
We investigated the effects of dietary supplementation of difructose anhydride III (DFA III), raffinose (Raf), and fructooligosaccharides (FOS) on diet-induced obesity development. Male rats were fed normal or high-fat and high-sucrose (HFS) diet, with or without supplementing (3%) DFA III, Raf, or FOS, for 8 or 5 weeks. Supplementing DFA III to the HFS diet decreased energy intake compared to the non-supplemented HFS diet. Accordingly, body weight gain and fat accumulation reduced in DFA III-fed rats. Cecal acetate production and plasma glucagon-like peptide-1 (GLP-1) and peptide-YY (PYY) were elevated in DFA III-fed rats, while Raf and FOS partially affected these parameters. These results demonstrate that DFA III has suppressive effect on excessive energy intake driven by the palatable obesogenic diet, possibly due to combined effects of increased anorexigenic factors such as cecal acetate production and GLP-1/PYY secretion.
我们研究了膳食补充二果糖酐III（DFA III）、棉子糖（Raf）和低聚果糖（FOS）对饮食诱导的肥胖发生发展的影响。雄性大鼠分别喂食正常饮食或高脂高糖（HFS）饮食，同时添加或不添加（3%）DFA III、Raf或FOS，持续8周或5周。与未添加DFA III的HFS饮食相比，在HFS饮食中添加DFA III可降低能量摄入。因此，喂食DFA III的大鼠体重增加和脂肪堆积减少。喂食DFA III的大鼠盲肠乙酸盐生成以及血浆胰高血糖素样肽-1（GLP-1）和肽YY（PYY）升高，而Raf和FOS对这些参数有部分影响。这些结果表明，DFA III对由美味致肥胖饮食驱动的过量能量摄入具有抑制作用，这可能是由于盲肠乙酸盐生成和GLP-1/PYY分泌等厌食因子增加的综合作用所致。
