Department of Food Science and Biotechnology, National Chung Hsing University, 145 Xingda Road, Taichung 40227, Taiwan.
Syngen Biotech Co., Ltd., Building A, No. 154, Kaiyuan Rd., Sinying, Tainan 73055, Taiwan.
Molecules. 2018 Aug 28;23(9):2169. doi: 10.3390/molecules23092169.
This study investigated the effects of incorporating a mixture of fructooligosaccharide (FOS) and resistant maltodextrin (RMD) at a ratio of 1:2 on body fat accumulation and fecal bacterial parameters in rats. Our results indicated that high dietary fat consumption might effectively ( < 0.05) increase body fat, but consequently inducing a significantly ( < 0.05) higher growth of and retarded growth ( < 0.05) of the spp. in the large intestine. As compared with the high fat control, an incorporation of the FOS and RMD mixture at a high dose (0.97 and 1.94 g/kg body weight, respectively) could result in a significant ( < 0.05) reduction in feed efficiency (-16%), total visceral fat (-17.4%), non-visceral fat levels (-20.3%), and total body fat (-19.2%). Furthermore, feeding the FOS and RMD mixture at a high dose was capable to counter the above undesirable impacts by reducing the count (-14.8%) and increasing the total count (134.4%) and total fecal short chain fatty acids (195.4%). A supplementation of adequate amount of FOS and RMD might confer a concreted solution to the obesity and deteriorated fecal bacteria profiles due to high fat consumption.
本研究探讨了在 1:2 的比例下将低聚果糖（FOS）和抗性麦芽糊精（RMD）混合物添加到饮食中对大鼠体脂肪积累和粪便细菌参数的影响。我们的结果表明，高脂肪饮食可能会有效地（<0.05）增加体脂肪，但会导致大肠中 和 显著增加（<0.05），而 生长受抑制（<0.05）。与高脂肪对照组相比，高剂量（分别为 0.97 和 1.94 g/kg 体重）的 FOS 和 RMD 混合物的添加可导致饲料效率显著降低（-16%），总内脏脂肪（-17.4%），非内脏脂肪水平（-20.3%）和总体脂肪（-19.2%）。此外，高剂量喂养 FOS 和 RMD 混合物能够通过减少 计数（-14.8%）和增加总 计数（134.4%）和总粪便短链脂肪酸（195.4%）来抵消上述不良影响。适量补充 FOS 和 RMD 可能为由于高脂肪摄入导致的肥胖和粪便细菌谱恶化提供具体的解决方案。
