LINE-1 在小鼠胚胎染色质调控中的精细作用
A fine LINE-1 in mouse embryonic chromatin regulation.
机构信息
Department of Oncological Sciences, Huntsman Cancer Institute and Howard Hughes Medical Institute, Salt Lake City, Utah, USA.
出版信息
Nat Genet. 2017 Sep 27;49(10):1418-1419. doi: 10.1038/ng.3960.
DOI:10.1038/ng.3960
PMID:28951621
Abstract
The functional role of repetitive elements in mammalian genomes is still largely unexplored. A new study provides evidence that LINE-1 retrotransposons regulate chromatin dynamics and are essential for normal embryonic development in mice.
摘要
哺乳动物基因组中重复元件的功能作用在很大程度上仍未被探索。一项新的研究提供了证据，表明 LINE-1 反转录转座子调节染色质动力学，并且对于小鼠正常胚胎发育是必不可少的。
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