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促肾上腺皮质激素释放激素系统在扁平苔藓的发病机制中起作用吗？

Does the corticotropin-releasing hormone system play a role in the pathogenesis of lichen planus?

作者信息

Cemil Bengu Cevirgen, Yilmazer Demet, Atas Hatice, Cengiz Fatma Pelin, Canpolat Filiz, Alper Murat, Gonul Muzeyyen

机构信息

Department of Dermatology, University of Health Sciences, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey.

Department of Pathology, University of Health Sciences, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey.

出版信息

Postepy Dermatol Alergol. 2017 Aug;34(4):322-327. doi: 10.5114/ada.2017.69311. Epub 2017 Aug 1.

DOI:10.5114/ada.2017.69311
PMID:28951706
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5560179/
Abstract

INTRODUCTION

Lichen planus (LP) is a chronic inflammatory disease, where the psychogenic factors seem to play an important role in the pathogenesis.

AIM

To determine the expression of corticotropin-releasing hormone (CRH) receptor type 1 (CRH-R1) in LP.

MATERIAL AND METHODS

Thirty-two LP patients and 17 age/gender-matched controls were included in the study. Detailed information about the disease and body surface area (BSA) covered by the lesions was recorded. Immunohistochemically, the expression of CRH-R1 was stained in the lesional skin of patients with LP and in the control group.

RESULTS

The comparison of CRH-R1 expression showed a statistically significant difference between LP patients and the controls ( < 0.05). Additionally, we did not observe any correlation between BSA and staining intensity in LP patients.

CONCLUSIONS

Our study showed an increase in CRH-R1 expression in LP lesions. These results support the participation of the cutaneous CRH/CRH-R1 system in the pathogenesis of LP skin lesions.

摘要

引言

扁平苔藓（LP）是一种慢性炎症性疾病，心理因素似乎在其发病机制中起重要作用。

目的

确定1型促肾上腺皮质激素释放激素（CRH）受体（CRH-R1）在扁平苔藓中的表达。

材料与方法

本研究纳入了32例扁平苔藓患者和17例年龄及性别匹配的对照。记录了有关疾病及皮损覆盖的体表面积（BSA）的详细信息。采用免疫组织化学方法，对扁平苔藓患者的皮损及对照组进行CRH-R1表达染色。

结果

CRH-R1表达比较显示，扁平苔藓患者与对照组之间存在统计学显著差异（<0.05）。此外，我们未观察到扁平苔藓患者的体表面积与染色强度之间存在任何相关性。

结论

我们的研究显示扁平苔藓皮损中CRH-R1表达增加。这些结果支持皮肤CRH/CRH-R1系统参与扁平苔藓皮肤损害的发病机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20d5/5560179/4518f2364ecf/PDIA-34-30416-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20d5/5560179/4518f2364ecf/PDIA-34-30416-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20d5/5560179/4518f2364ecf/PDIA-34-30416-g001.jpg

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Lupus. 2015 Jul;24(8):854-61. doi: 10.1177/0961203315569335. Epub 2015 Jan 28.
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Key role of CRF in the skin stress response system.CRF 在皮肤应激反应系统中的关键作用。
Endocr Rev. 2013 Dec;34(6):827-84. doi: 10.1210/er.2012-1092. Epub 2013 Aug 12.
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Oral lichen planus: focus on etiopathogenesis.口腔扁平苔藓：关注病因发病机制。
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Oral lichen planus.口腔扁平苔藓
An Bras Dermatol. 2011 Jul-Aug;86(4):633-41; quiz 642-3. doi: 10.1590/s0365-05962011000400002.
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Diagnosis and treatment of lichen planus.扁平苔藓的诊断与治疗。
Am Fam Physician. 2011 Jul 1;84(1):53-60.
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