He Jiayuan, Gui Shilang, Huang Yanyan, Hu Fang, Jin Yulong, Yu Yang, Zhang Guanxin, Zhang Deqing, Zhao Rui
CAS Key Laboratories of Analytical Chemistry for Living Biosystems and Organic Solids, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.
Chem Commun (Camb). 2017 Oct 5;53(80):11091-11094. doi: 10.1039/c7cc06485c.
A fast and sensitive method was established for an in-solution selection of cancer cell-targeting peptides at "single-residue resolution" by using the switchable fluorescence of tetraphenylethylene. The selected peptides have potential for biomarker tracing and can be used for targeted delivery of different cargos into living cancer cells.
通过利用四苯乙烯的可切换荧光，建立了一种快速灵敏的方法，用于在“单残基分辨率”下在溶液中筛选癌细胞靶向肽。所筛选出的肽具有生物标志物追踪的潜力，可用于将不同的货物靶向递送至活的癌细胞中。
