一种基于聚集诱导发光四苯乙烯衍生物的用于活细胞中β-半乳糖苷酶活性检测与成像的选择性点亮型荧光探针。
A selective and light-up fluorescent probe for β-galactosidase activity detection and imaging in living cells based on an AIE tetraphenylethylene derivative.
作者信息
Jiang Guoyu, Zeng Guanjie, Zhu Wenping, Li Yongdong, Dong Xiaobiao, Zhang Guanxin, Fan Xiaolin, Wang Jianguo, Wu Yongquan, Tang Ben Zhong
机构信息
Key Laboratory of Organo-Pharmaceutical Chemistry, Gannan Normal University, Ganzhou 341000, P. R. China.
出版信息
Chem Commun (Camb). 2017 Apr 18;53(32):4505-4508. doi: 10.1039/c7cc00249a.
PMID:28383580
Abstract
An aggregation induced emission (AIE) based bioimaging probe, TPE-Gal, was designed for light-up imaging of β-galactosidase in living cells. The applicability of TPE-Gal in imaging endogenous β-galactosidase activity was confirmed in OVCAR-3 cells.
摘要
一种基于聚集诱导发光（AIE）的生物成像探针TPE-Gal被设计用于活细胞中β-半乳糖苷酶的点亮成像。TPE-Gal在内源性β-半乳糖苷酶活性成像中的适用性在OVCAR-3细胞中得到了证实。
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