Department of Materials Science and Engineering, National Chiao Tung University, Hsinchu, 300, Taiwan.
Department of Chemistry, Chung Yuan Christian University, Taoyuan, 320, Taiwan.
Chem Commun (Camb). 2019 Jan 25;55(8):1060-1063. doi: 10.1039/c8cc08679f. Epub 2019 Jan 8.
We report a novel fluorescent bioprobe, tetraphenylethylene-Phe-Asp-Gly-Glu-Ala (TPE-FDGEA), and its self-assembly behavior, photophysical properties, and biocompatibility. The hydrogelator TPE-FDGEA exhibited aggregation-induced emission characteristics, which facilitated imaging of PC-3 human prostate cancer cells, thereby demonstrating the utility of such fluorescent probes for specific labeling of target cells in vitro.
我们报道了一种新型荧光生物探针，四苯乙烯-苯丙氨酸-天冬氨酸-甘氨酸-谷氨酸-丙氨酸（TPE-FDGEA），及其自组装行为、光物理性质和生物相容性。水凝胶因子 TPE-FDGEA 表现出聚集诱导发射特性，有利于人前列腺癌细胞 PC-3 的成像，从而证明了这种荧光探针在体外靶向细胞特异性标记中的应用。
