Tzeng Nian-Sheng, Chung Chi-Hsiang, Lin Fu-Huang, Huang Ching-Feng, Yeh Chin-Bin, Huang San-Yuan, Lu Ru-Band, Chang Hsin-An, Kao Yu-Chen, Yeh Hui-Wen, Chiang Wei-Shan, Chou Yu-Ching, Tsao Chang-Huei, Wu Yung-Fu, Chien Wu-Chien
a Department of Psychiatry , Tri-Service General Hospital, School of Medicine, National Defense Medical Center , Taipei , Taiwan , ROC.
b Student Counseling Center , National Defense Medical Center , Taipei , Taiwan , ROC.
Curr Med Res Opin. 2018 Jan;34(1):163-169. doi: 10.1080/03007995.2017.1385449. Epub 2017 Oct 30.
Dietary magnesium may be associated with a lower risk of dementia; however, the impact of magnesium oxide (MgO), a common laxative, on dementia has yet to be elucidated. This study aimed to investigate the association between the usage of MgO and the risk of developing dementia.
We used a dataset from the National Health Research Institute Database (NHRID) of Taiwan containing one million randomly sampled subjects to identify patients aged ≥50 years with no history of MgO usage. A total of 1547 patients who had used MgO were enrolled, along with 4641 controls who had not used the MgO propensity score matched by age, gender and comorbidity, at a ratio of 1:3. After adjusting for confounding risk factors, a Cox proportional hazards model was used to compare the risk of developing dementia during a 10 year follow-up period.
Of the enrolled patients, 44 (2.84%) developed dementia, when compared to 199 (4.28%) in the control group. The Cox proportional hazards regression analysis revealed that the patients who had used MgO were less likely to develop dementia with a crude hazard ratio of 0.617 (95% CI, 0.445-0.856, p = .004). After adjusting for age, gender, comorbidity, geographical area and urbanization level of residence, and monthly income, the adjusted hazard ratio was 0.517 (95% CI, 0.412-0.793, p = .001).
The patients who used MgO had a decreased risk of developing dementia. Further studies on the effects of MgO in reducing the risk of dementia are therefore warranted.
膳食镁可能与较低的痴呆风险相关；然而，常见泻药氧化镁（MgO）对痴呆的影响尚未阐明。本研究旨在调查氧化镁的使用与患痴呆风险之间的关联。
我们使用了来自台湾国家卫生研究院数据库（NHRID）的数据集，其中包含100万随机抽样的受试者，以识别年龄≥50岁且无氧化镁使用史的患者。共纳入1547名使用过氧化镁的患者，以及4641名未使用氧化镁的对照者，后者按年龄、性别和合并症进行倾向得分匹配，比例为1:3。在调整混杂风险因素后，使用Cox比例风险模型比较10年随访期内患痴呆的风险。
在纳入的患者中，44例（2.84%）发生痴呆，而对照组为199例（4.28%）。Cox比例风险回归分析显示，使用氧化镁的患者患痴呆的可能性较小，粗风险比为0.617（95%CI，0.445-0.856，p = 0.004）。在调整年龄、性别、合并症、居住地理区域和城市化水平以及月收入后，调整后的风险比为0.517（95%CI，0.412-0.793，p = 0.001）。
使用氧化镁的患者患痴呆的风险降低。因此，有必要进一步研究氧化镁在降低痴呆风险方面的作用。
