注意缺陷多动障碍（ADHD）成人的痴呆风险：一项基于人群的全台湾地区队列研究。
Risk of Dementia in Adults With ADHD: A Nationwide, Population-Based Cohort Study in Taiwan.
机构信息
1 Department of Psychiatry, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China.
2 Student Counseling Center, National Defense Medical Center, Taipei, Taiwan, Republic of China.
出版信息
J Atten Disord. 2019 Jul;23(9):995-1006. doi: 10.1177/1087054717714057. Epub 2017 Jun 19.
OBJECTIVE
This study aimed to investigate the association between adults with ADHD and the risk of developing dementia.
METHOD
Utilizing National Health Insurance Research Database of Taiwan, ADHD patients were identified and compared with age- and gender-matched controls (1:3).
RESULTS
Of the study participants, 37 (5.48%) developed dementia compared with 81 (4.0%) in the control group. Cox proportional hazards regression analysis revealed that the study participants were more likely to develop dementia. The crude hazard ratio (HR) is 3.418 (95% confidence interval [CI] = [2.289, 5.106], p < .001), and adjusted HR is 4.008 (95% CI = [2.526, 6.361], p < .001) in risk of developing dementia after adjusted for age, gender, comorbidities, geographical area of residence, urbanization level of residence, and monthly income.
CONCLUSION
Adults with ADHD have a 3.4-fold risk of developing dementia, and other large or national data sets should be explored to support the current findings.
目的
本研究旨在探讨成人注意力缺陷多动障碍（ADHD）与痴呆风险之间的关系。
方法
利用台湾全民健康保险研究数据库，识别出 ADHD 患者，并与年龄和性别相匹配的对照组（1:3）进行比较。
结果
在研究参与者中，37 人（5.48%）发展为痴呆，而对照组为 81 人（4.0%）。Cox 比例风险回归分析显示，研究参与者发生痴呆的风险更高。粗危险比（HR）为 3.418（95%置信区间[CI] = [2.289, 5.106]，p <.001），调整年龄、性别、合并症、居住地区、居住城市化水平和月收入后，调整 HR 为 4.008（95% CI = [2.526, 6.361]，p <.001）。
结论
成人 ADHD 患痴呆的风险增加 3.4 倍，应探索其他大型或全国性数据集来支持当前的研究结果。
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