Beyaz Şengül, Ükinç Kubilay
Department of Endocrinology and Metabolic Diseases, Florence Nightingale Hospital, İstanbul, Turkey.
Turk Kardiyol Dern Ars. 2017 Apr;45(Suppl 3):13-15. doi: 10.5543/tkda.2017.51635.
Managing dyslipidaemia is central to the management of cardiovascular disease. Statins are the cornerstone of cardiovascular prevention for general population, and in patients with type 2 diabetes mellitus. However, statin therapy predisposes to type 2 diabetes, particularly in patients with predisposition to this condition. Some statins have been associated with increases in blood glucose in patients, and others have shown to have neutral effects, varying from one another their glucose or diabetogenic capacity. Pitavastatin is a new member of the statin class. And pitavastatin has a number of pleiotropic effects that can reduce inflammation and lipid oxidation, improve endothelial function, reduce the metabolic changes associated with adiposity, and improve glucose metabolism and renal function.
管理血脂异常是心血管疾病管理的核心。他汀类药物是普通人群以及2型糖尿病患者心血管预防的基石。然而，他汀类药物治疗易引发2型糖尿病，尤其是在易患此病的患者中。一些他汀类药物与患者血糖升高有关，而其他一些则显示出中性作用，它们的血糖或致糖尿病能力各不相同。匹伐他汀是他汀类药物中的新成员。匹伐他汀具有多种有益作用，可减轻炎症和脂质氧化、改善内皮功能、减少与肥胖相关的代谢变化，并改善葡萄糖代谢和肾功能。
