Lee Seung Hwan, Sung Jong Hwan
School of Chemical and Biological Engineering, Seoul National University, Seoul 151-742, Korea.
Department of Chemical Engineering, Hongik University, Seoul 121-791, Korea.
Bioengineering (Basel). 2017 May 21;4(2):46. doi: 10.3390/bioengineering4020046.
Drugs affect the human body through absorption, distribution, metabolism, and elimination (ADME) processes. Due to their importance, the ADME processes need to be studied to determine the efficacy and side effects of drugs. Various in vitro model systems have been developed and used to realize the ADME processes. However, conventional model systems have failed to simulate the ADME processes because they are different from in vivo, which has resulted in a high attrition rate of drugs and a decrease in the productivity of new drug development. Recently, a microtechnology-based in vitro system called "organ-on-a-chip" has been gaining attention, with more realistic cell behavior and physiological reactions, capable of better simulating the in vivo environment. Furthermore, multi-organ-on-a-chip models that can provide information on the interaction between the organs have been developed. The ultimate goal is the development of a "body-on-a-chip", which can act as a whole body model. In this review, we introduce and summarize the current progress in the development of multi-organ models as a foundation for the development of body-on-a-chip.
药物通过吸收、分布、代谢和排泄（ADME）过程影响人体。由于这些过程的重要性，需要对ADME过程进行研究，以确定药物的疗效和副作用。已经开发并使用了各种体外模型系统来实现ADME过程。然而，传统的模型系统未能模拟ADME过程，因为它们与体内情况不同，这导致了药物的高淘汰率和新药开发生产力的下降。最近，一种基于微技术的体外系统“芯片器官”受到了关注，它具有更逼真的细胞行为和生理反应，能够更好地模拟体内环境。此外，已经开发出了能够提供器官间相互作用信息的多芯片器官模型。最终目标是开发出一种“芯片人体”，它可以作为一个整体人体模型。在这篇综述中，我们介绍并总结了多器官模型开发的当前进展，作为芯片人体开发的基础。
