载多柔比星的植物病毒纳米颗粒在癌症临床前模型中的药代动力学和疗效。
Pharmacokinetics and efficacy of doxorubicin-loaded plant virus nanoparticles in preclinical models of cancer.
机构信息
Division of Pharmacotherapy & Experimental Therapeutics, University of North Carolina at Chapel Hill (UNC) Eshelman School of Pharmacy, Chapel Hill, NC, USA.
Nanovector Inc., Raleigh, NC, USA.
出版信息
Nanomedicine (Lond). 2017 Oct;12(20):2519-2532. doi: 10.2217/nnm-2016-0421. Epub 2017 Sep 27.
AIM
To compare the pharmacokinetics and efficacy of doxorubicin containing plant virus nanoparticles (PVNs) with PEGylated liposomal doxorubicin (PLD) and small molecule doxorubicin in two mouse models of cancer.
MATERIALS & METHODS: Studies were performed in A375 melanoma and intraperitoneal SKOV3ip1 ovarian cancer xenografts. The PVNs were administered in lower and more frequent doses in the ovarian model.
RESULTS
The PVNs were more efficacious than PLD and small molecule doxorubicin in the ovarian cancer model, but not in the melanoma cancer model. The pharmacokinetics profiles of the PVNs showed fast plasma clearance, but more efficient tumor delivery as compared with other carrier-mediated agents.
CONCLUSION
PVNs administered at lower repeated doses provide both pharmacologic and efficacy advantages compared with PLD.
目的
比较载多柔比星植物病毒纳米粒（PVNs）与聚乙二醇化脂质体多柔比星（PLD）和小分子多柔比星在两种癌症小鼠模型中的药代动力学和疗效。
材料与方法
在 A375 黑色素瘤和腹腔内 SKOV3ip1 卵巢癌异种移植模型中进行了研究。在卵巢模型中，PVNs 以更低和更频繁的剂量给药。
结果
PVNs 在卵巢癌模型中比 PLD 和小分子多柔比星更有效，但在黑色素瘤癌症模型中无效。PVNs 的药代动力学特征显示快速血浆清除，但与其他载体介导的药物相比，更有效地将药物递送到肿瘤部位。
结论
与 PLD 相比，以较低的重复剂量给予 PVNs 可提供药理和疗效优势。
Zotero 插件