Hefferon Kathleen L
Department of Food Sciences, Cornell University, Ithaca, NY 14886, USA.
Vaccines (Basel). 2018 Feb 14;6(1):11. doi: 10.3390/vaccines6010011.
Plants have been explored for many years as inexpensive and versatile platforms for the generation of vaccines and other biopharmaceuticals. Plant viruses have also been engineered to either express subunit vaccines or act as epitope presentation systems. Both icosahedral and helical, filamentous-shaped plant viruses have been used for these purposes. More recently, plant viruses have been utilized as nanoparticles to transport drugs and active molecules into cancer cells. The following review describes the use of both icosahedral and helical plant viruses in a variety of new functions against cancer. The review illustrates the breadth of variation among different plant virus nanoparticles and how this impacts the immune response.
多年来，植物一直被探索作为生产疫苗和其他生物制药的廉价且通用的平台。植物病毒也已被改造用于表达亚单位疫苗或作为表位呈递系统。二十面体和螺旋状的丝状植物病毒都已被用于这些目的。最近，植物病毒已被用作纳米颗粒，将药物和活性分子输送到癌细胞中。以下综述描述了二十面体和螺旋状植物病毒在针对癌症的各种新功能中的应用。该综述说明了不同植物病毒纳米颗粒之间的差异程度以及这如何影响免疫反应。
