Wu Qiang, Luo Wuxia, Zhao Yaqin, Xu Feng, Zhou Qinghua
aLung Cancer Center bDepartment of Abdominal Cancer, Cancer Center, West China Hospital, Sichuan University cDepartment of Medical Oncology, the First People's Hospital of Chengdu, Chengdu, China.
Nucl Med Commun. 2017 Dec;38(12):1117-1124. doi: 10.1097/MNM.0000000000000757.
The aim of the present meta-analysis was to systematically evaluate the overall diagnostic accuracy of F-FDG PET/CT for the detection of adrenal metastasis in lung cancer.
A comprehensive literature search of Medline (PubMed), Embase, Web of Science, Cochrane, and China National Knowledge Infrastructure databases published through 10 January 2017 on the role of F-FDG PET/CT in evaluating adrenal mass in lung cancer patients was performed. Pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio of F-FDG PET/CT on a per lesion-based analysis were calculated. The area under the curve was calculated to measure the accuracy of F-FDG PET/CT.
A total of nine studies, involving 707 lung cancer patients with 810 adrenal masses, were included in the present meta-analysis. Of 810 adrenal masses from lung cancer, 411 (50.7%) and 399 (49.3%) masses were benign and metastatic, respectively. The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio of F-FDG PET/CT were 0.887 [95% confidence interval (CI): 0.852-0.917], 0.908 (95% CI: 0.875-0.934), 8.552 (95% CI: 6.197-11.802), 0.090 (95% CI: 0.039-0.211), and 96.825 (95% CI: 40.402-232.05), respectively. In addition, the area under the curve was 0.9622 and the overall diagnostic accuracy (Q* index) was 0.9077, suggesting excellent performance.
F-FDG PET/CT plays a vital role in the differentiation of adrenal metastasis from a benign adrenal mass in lung cancer patients, with excellent diagnostic performance.
本荟萃分析旨在系统评估F-FDG PET/CT检测肺癌肾上腺转移的总体诊断准确性。
对截至2017年1月10日发表在Medline（PubMed）、Embase、Web of Science、Cochrane及中国知网数据库中关于F-FDG PET/CT在评估肺癌患者肾上腺肿块中的作用的文献进行全面检索。计算基于每个病灶分析的F-FDG PET/CT的合并敏感度、特异度、阳性似然比、阴性似然比及诊断比值比。计算曲线下面积以衡量F-FDG PET/CT的准确性。
本荟萃分析共纳入9项研究，涉及707例肺癌患者及810个肾上腺肿块。在810个肺癌患者的肾上腺肿块中，分别有411个（50.7%）为良性，399个（49.3%）为转移性。F-FDG PET/CT的合并敏感度、特异度、阳性似然比、阴性似然比及诊断比值比分别为0.887[95%置信区间（CI）：0.852 - 0.917]、0.908（95% CI：0.875 - 0.934）、8.552（95% CI：6.197 - 11.802）、0.090（95% CI：0.039 - 0.211）及96.825（95% CI：40.402 - 232.05）。此外，曲线下面积为0.9622，总体诊断准确性（Q*指数）为0.9077，提示其表现优异。
F-FDG PET/CT在鉴别肺癌患者肾上腺转移与良性肾上腺肿块中起着至关重要的作用，具有优异的诊断性能。
