Meta 分析：18FDG PET-CT 对肺癌患者远处转移分期的准确性。
Meta-analysis: accuracy of 18FDG PET-CT for distant metastasis staging in lung cancer patients.
机构信息
Department of Oncology, The No. 456 Hospital of People's Liberation Army, Jinan 250031, PR China.
出版信息
Surg Oncol. 2013 Sep;22(3):151-5. doi: 10.1016/j.suronc.2013.04.001. Epub 2013 May 9.
BACKGROUND
We undertook a meta-analysis to evaluate the accuracy of (18)FDG PET-CT for diagnosis of distant metastases in lung cancer patients.
METHODS
Studies about (18)FDG PET-CT for diagnosis of distant metastases in patients with lung cancer were systematically searched in the MEDLINE and EMBASE databases. We calculated sensitivities, specificities, positive likelihood ratios and negative likelihood ratios, and constructed summary receiver operating characteristic curves using bivariate regression models for (18)FDG PET-CT.
RESULTS
Across 9 studies (780 patients), the sensitivity, specificity, positive likelihood ratio and negative likelihood ratio of (18)FDG PET-CT were 0.93 (95% confidence interval [CI] = 0.88-0.96), 0.96 (95% CI = 0.95-0.96), 28.4 (95% CI = 14.0-57.5), and 0.08 (95% CI = 0.02-0.37), respectively. Overall weighted area under the curve was 0.98 (95% CI = 0.96-0.99).
CONCLUSION
(18)FDG PET-CT has excellent diagnostic performance for diagnosis of distant metastases in patients with lung cancer.
背景
我们进行了一项荟萃分析，以评估（18）FDG PET-CT 对肺癌患者远处转移诊断的准确性。
方法
系统检索 MEDLINE 和 EMBASE 数据库中关于（18）FDG PET-CT 诊断肺癌患者远处转移的研究。我们使用双变量回归模型计算（18）FDG PET-CT 的敏感性、特异性、阳性似然比和阴性似然比，并构建汇总受试者工作特征曲线。
结果
共纳入 9 项研究（780 例患者），（18）FDG PET-CT 的敏感性、特异性、阳性似然比和阴性似然比分别为 0.93（95%置信区间 [CI] = 0.88-0.96）、0.96（95% CI = 0.95-0.96）、28.4（95% CI = 14.0-57.5）和 0.08（95% CI = 0.02-0.37），总曲线下面积为 0.98（95% CI = 0.96-0.99）。
结论
（18）FDG PET-CT 对肺癌患者远处转移的诊断具有优异的诊断性能。
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