在申克孢子丝菌复合体的菌种中，巴西孢子丝菌在小鼠模型中产生的氧化应激水平最高。
Sporothrix brasiliensis produces the highest levels of oxidative stress in a murine model among the species of the Sporothrix schenckii complex.
作者信息
Mario Débora Nunes, Schaffer Larissa Finger, Peroza Luis Ricardo, Jesus Francielli Pantella Kunz de, Denardi Laura Bedin, Fachinetto Roselei, Alves Sydney Hartz
机构信息
Escola de Saúde, Imed, Passo Fundo, RS, Brasil.
Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal de Santa Maria, Santa Maria, RS, Brasil.
出版信息
Rev Soc Bras Med Trop. 2017 Jul-Aug;50(4):554-557. doi: 10.1590/0037-8682-0171-2016.
INTRODUCTION
: We compared indicators of oxidative stress in the tissue of mice infected with strains from Sporothrix schenckii complex.
METHODS
: Mice were inoculated with Sporothrix brasiliensis, Sporothrix schenckii sensu stricto, Sporothrix globosa, Sporothrix mexicana or Sporothrix albicans. The activity of catalase and glutathione were accessed in the liver and spleen.
RESULTS
: Animals infected with S. brasiliensis exhibited splenomegaly and significant decrease in catalase activity, and protein and non-protein thiol content compared to animals infected with the other species.
CONCLUSIONS
: Sporothrix brasiliensis exhibits higher pathogenicity compared to other species of the Sporothrix schenckii complex by increasing oxidative stress in animal tissue.
引言
我们比较了感染申克孢子丝菌复合体菌株的小鼠组织中的氧化应激指标。
方法
用巴西孢子丝菌、狭义申克孢子丝菌、球形孢子丝菌、墨西哥孢子丝菌或白色孢子丝菌接种小鼠。检测肝脏和脾脏中过氧化氢酶和谷胱甘肽的活性。
结果
与感染其他菌种的动物相比，感染巴西孢子丝菌的动物出现脾肿大，过氧化氢酶活性、蛋白质和非蛋白质硫醇含量显著降低。
结论
巴西孢子丝菌通过增加动物组织中的氧化应激，表现出比申克孢子丝菌复合体其他菌种更高的致病性。
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