Misumi A, Shiratori K, Lee K Y, Barkin J S, Chey W Y
Genesee Hospital, Rochester, NY 14607.
Surgery. 1988 Apr;103(4):450-5.
The effect of SMS 201-995, an analogue of somatostatin, on pancreatic exocrine secretion was investigated in both interdigestive and digestive states in dogs. In four dogs with gastric and Thomas duodenal cannulas, the pancreatic juice was collected by direct cannulation of the main pancreatic duct. SMS 201-995 was infused intravenously at doses of 0, 15, 30, 60, and 120 ng/kg/hr for 2 to 3 hours in the following experimental conditions: (1) interdigestive pancreatic secretion, (2) pancreatic secretion stimulated by the intravenous infusion of both secretin, 0.06 CU/kg/hr, and cholecystokinin octapeptide (CCK8), 0.03 microgram/kg/hr, and (3) pancreatic secretion after ingestion of a test meal. Pancreatic juice was analyzed for volume and outputs of bicarbonate and protein. Plasma levels of motilin, pancreatic polypeptide (PP), CCK, and secretin were determined by radioimmunoassay. SMS 201-995 inhibited significantly the pancreatic secretion and release of hormones, including secretin, CCK, PP, and motilin, in all three experimental conditions. The inhibitory action of SMS 201-995 on pancreatic secretion and hormone releases was dose dependent.
在犬的消化间期和消化期，研究了生长抑素类似物SMS 201 - 995对胰腺外分泌的影响。在4只装有胃和十二指肠套管的犬中，通过直接插管主胰管收集胰液。在以下实验条件下，以0、15、30、60和120 ng/kg/hr的剂量静脉输注SMS 201 - 995，持续2至3小时：(1)消化间期胰腺分泌；(2)通过静脉输注促胰液素（0.06 CU/kg/hr）和八肽胆囊收缩素（CCK8，0.03微克/kg/hr）刺激的胰腺分泌；(3)进食试验餐后的胰腺分泌。分析胰液的体积以及碳酸氢盐和蛋白质的分泌量。通过放射免疫分析法测定血浆中胃动素、胰多肽（PP）、CCK和促胰液素的水平。在所有三种实验条件下，SMS 201 - 995均显著抑制胰腺分泌以及包括促胰液素、CCK、PP和胃动素在内的激素释放。SMS 201 - 995对胰腺分泌和激素释放的抑制作用呈剂量依赖性。
