Chinda Daisuke, Shimoyama Tadashi, Hayamizu Shiro, Miyazawa Kuniaki, Arai Tetsu, Yanagimachi Miyuki, Tsukamoto Toshiaki, Mikami Tatsuya, Fukuda Shinsaku
Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori 036-8562, Japan.
Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori 036-8562, Japan.
J Clin Biochem Nutr. 2017 Sep;61(2):153-157. doi: 10.3164/jcbn.17-16. Epub 2017 Aug 18.
The aim of this study was to investigate the change in the energy metabolism and invasiveness in the perioperative period of endoscopic submucosal dissection for early gastric cancer. Fifty-two consecutive patients were enrolled into the study between July 2013 and May 2014 and examined resting energy expenditure using an indirect calorimeter, body weight and basal energy expenditure using the Harris-Benedict equation before and after endoscopic submucosal dissection. Resting energy expenditure/body weight and resting energy expenditure/basal energy expenditure were 20.2 ± 3.0 kcal/kg/day and 0.96 ± 0.11 on the day of endoscopic submucosal dissection, whereas one day after the endoscopic submucosal dissection they were 21.7 ± 3.2 kcal/kg/day and 1.03 ± 0.14, showing significant increases (<0.001, respectively). The stress factor on the postoperative day 1 was computed as 1.07. This increase was low in comparison to that experienced for surgery, suggesting that the degree of perioperative invasiveness in patients receiving endoscopic submucosal dissection is lower in comparison to that during surgery (The study of the resting energy metabolism and stress factor using an indirect calorimeter in the perioperative period of endoscopic operation: UMIN000027135).
本研究旨在探讨早期胃癌内镜黏膜下剥离术围手术期能量代谢及侵袭性的变化。2013年7月至2014年5月期间,连续纳入52例患者,在内镜黏膜下剥离术前及术后,使用间接测热法检测静息能量消耗,使用哈里斯-本尼迪克特方程计算体重及基础能量消耗。内镜黏膜下剥离术当天静息能量消耗/体重及静息能量消耗/基础能量消耗分别为20.2±3.0kcal/kg/天和0.96±0.11,而在内镜黏膜下剥离术后一天,它们分别为21.7±3.2kcal/kg/天和1.03±0.14,均显著增加(分别<0.001)。术后第1天的应激因子计算为1.07。与手术时相比,这种增加较低,表明接受内镜黏膜下剥离术患者的围手术期侵袭程度低于手术期间(在内镜手术围手术期使用间接测热法研究静息能量代谢及应激因子:UMIN000027135)。