Bales Karen L, Arias Del Razo Rocío, Conklin Quinn A, Hartman Sarah, Mayer Heather S, Rogers Forrest D, Simmons Trenton C, Smith Leigh K, Williams Alexia, Williams Donald R, Witczak Lynea R, Wright Emily C
Department of Psychology, University of California, Davis, CA.
California National Primate Research Center, Davis, CA.
Yale J Biol Med. 2017 Sep 25;90(3):373-387. eCollection 2017 Sep.
It is now widely recognized that social bonds are critical to human health and well-being. One of the most important social bonds is the attachment relationship between two adults, known as the . The pair bond involves many characteristics that are inextricably linked to quality of health, including providing a secure psychological base and acting as a social buffer against stress. The majority of our knowledge about the neurobiology of pair bonding comes from studies of a socially monogamous rodent, the prairie vole (), and from human imaging studies, which inherently lack control. Here, we first review what is known of the neurobiology of pair bonding from humans and prairie voles. We then present a summary of the studies we have conducted in titi monkeys ()-a species of socially monogamous New World primates. Finally, we construct a neural model based on the location of neuropeptide receptors in the titi monkey brain, as well as the location of neural changes in our imaging studies, with some basic assumptions based on the prairie vole model. In this model, we emphasize the role of visual mating stimuli as well as contributions of the dopaminergic reward system and a strong role for the lateral septum. This model represents an important step in understanding the neurobiology of social bonds in non-human primates, which will in turn facilitate a better understanding of these mechanisms in humans.
现在人们普遍认识到，社会纽带对人类健康和幸福至关重要。最重要的社会纽带之一是两个成年人之间的依恋关系，即伴侣关系。伴侣关系涉及许多与健康质量紧密相连的特征，包括提供一个安全的心理基础以及作为抵御压力的社会缓冲。我们关于伴侣关系神经生物学的大部分知识来自对一种社会一夫一妻制啮齿动物——草原田鼠的研究，以及来自本质上缺乏对照的人类成像研究。在这里，我们首先回顾从人类和草原田鼠身上所知的伴侣关系神经生物学知识。然后我们总结我们在伶猴（一种社会一夫一妻制的新大陆灵长类动物）身上进行的研究。最后，我们基于伶猴大脑中神经肽受体的位置以及我们成像研究中神经变化的位置构建一个神经模型，并基于草原田鼠模型做出一些基本假设。在这个模型中，我们强调视觉交配刺激的作用以及多巴胺能奖赏系统的贡献，还有外侧隔的重要作用。这个模型是理解非人类灵长类动物社会纽带神经生物学的重要一步，这反过来将有助于更好地理解人类中的这些机制。
