Erickson Jami R, Gearhart Micah D, Honson Drew D, Reid Taylor A, Gardner Melissa K, Moriarity Branden S, Echeverri Karen
Department of Genetics, Cell Biology and Development, University of Minnesota, Minnesota, MN, USA.
Department of Pediatrics, University of Minnesota, Center for Genome Engineering, University of Minnesota, Masonic Cancer Center, University of Minnesota, Minnesota, MN USA.
NPJ Regen Med. 2016;1:16016-. doi: 10.1038/npjregenmed.2016.16. Epub 2016 Dec 8.
The human response to serious cutaneous damage is limited to relatively primitive wound healing, whereby collagenous scar tissue fills the wound bed. Scars assure structural integrity at the expense of functional regeneration. In contrast, axolotls have the remarkable capacity to functionally regenerate full thickness wounds. Here, we identified a novel role for SALL4 in regulating collagen transcription after injury that is essential for perfect skin regeneration in axolotl. Furthermore, we identify miR-219 as a molecular regulator of during wound healing. Taken together, our work highlights one molecular mechanism that allows for efficient cutaneous wound healing in the axolotl.
人类对严重皮肤损伤的反应仅限于相对原始的伤口愈合，即胶原瘢痕组织填充伤口床。瘢痕以功能再生为代价确保结构完整性。相比之下，蝾螈具有功能性再生全层伤口的非凡能力。在这里，我们确定了SALL4在损伤后调节胶原蛋白转录中的新作用，这对蝾螈完美的皮肤再生至关重要。此外，我们确定miR-219是伤口愈合过程中的一种分子调节因子。综上所述，我们的工作突出了一种允许蝾螈有效皮肤伤口愈合的分子机制。
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