关于突尼斯弱精子症男性线粒体DNA变异的“不育”研究。
'Infertile' studies on mitochondrial DNA variation in asthenozoospermic Tunisian men.
作者信息
Salas Antonio, Martinón-Torres Federico, Gómez-Carballa Alberto
机构信息
Unidade de Xenética, Departamento de Anatomía Patolóxica e Ciencias Forenses, Instituto de Ciencias Forenses, Facultade de Medicina, Universidade de Santiago de Compostela, and GenPop Research Group, Instituto de Investigaciones Sanitarias (IDIS), Hospital Clínico Universitario de Santiago, Galicia, Spain.
Grupo de Investigación en Genética, Vacunas, Infecciones y Pediatría (GENVIP), Hospital Clínico Universitario and Universidade de Santiago de Compostela, Galicia, Spain.
出版信息
Biochem Biophys Rep. 2016 Aug 11;8:114-119. doi: 10.1016/j.bbrep.2016.08.002. eCollection 2016 Dec.
We reviewed five studies undertaken by the same research group on the possible links between mitochondrial DNA (mtDNA) variation and asthenozoospermia, all carried out on Tunisian men. A thorough assessment of these articles reveals that all five studies were carried out on virtually the same cohort of patients, although this information was concealed by the authors. Thus, the results were 'sliced' in order to unjustifiably maximize the number of publications. In addition, a phylogenetic analysis of their data indicates that the reported results are notably incomplete and deficient. Overall, contrary to the original claims, the association of mtDNA variants with asthenozoospermia finds no support on this saga on Tunisian infertile men.
我们回顾了同一研究小组进行的五项关于线粒体DNA（mtDNA）变异与弱精子症之间可能联系的研究，所有研究均针对突尼斯男性开展。对这些文章进行全面评估后发现，尽管作者隐瞒了这一信息，但所有五项研究实际上都是在几乎相同的患者队列中进行的。因此，研究结果被“拆分”，以不合理地增加发表数量。此外，对其数据进行的系统发育分析表明，所报告的结果明显不完整且存在缺陷。总体而言，与最初的说法相反，在这一系列关于突尼斯不育男性的研究中，mtDNA变异与弱精子症之间的关联并未得到支持。
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