INEGI, LAETA, Faculty of Engineering of the University of Porto, Porto, 4200-465, Portugal.
J Mater Sci Mater Med. 2017 Sep 27;28(11):176. doi: 10.1007/s10856-017-5984-6.
The use of prostheses for hernia surgery, made from synthetic polymers may lead to development of postoperative complications. The reason for this can be the mismatch of the mechanical properties of meshes and the loads acting on them. The aim of this work was to investigate the behavior of 3 different hernia meshes under in vitro simulated physiological conditions followed by cyclic loadings. Meshes, Ultrapro (poliglecaprone and polypropylene), Dynamesh (polyvinylidenefluoride) and Surgipro (polypropylene) were selected. For in vitro degradation test, samples were kept in alkaline and acid mediums at 37 °C during 42 and 90 days and analyzed in terms of their weight loss and thickness changes. This was followed by cyclic loading in three increasing load stages. The greatest weight loss and thickness reduction were suffered by Ultrapro mesh. The mesh showed pH independent characteristics. Surgipro mesh had pH independent behavior due to the degradation process, with slight weight loss and thickness reduction. The degradation mechanism of Dynamesh is highly dependent on the pH, with acid surrounding medium acting as a degradation catalyst. Mechanical hysteresis was observed in all three meshes. The larger deformations occurred in Surgipro (25%); necking phenomenon was also observed. The deformation of Dynamesh was 22%, the mesh unweaves under applied load and was unable to withstand the third period of cyclic loads. Ultrapro mesh exhibits the lowest level of deformation (10%). Despite the different compositions and architectures of the meshes, all three underwent permanent plastic deformation, which will induce decreased mesh flexibility over time.
疝修补术中使用的合成聚合物假体可能会导致术后并发症的发生。其原因可能是网片的机械性能与作用在其上的负荷不匹配。本工作的目的是在体外模拟生理条件下，对 3 种不同疝修补网片进行循环加载，研究其行为。选择 Ultrapro（聚己内酯和聚丙烯）、Dynamesh（聚偏二氟乙烯）和 Surgipro（聚丙烯）网片进行体外降解试验。将样品分别置于碱性和酸性介质中，在 37°C 下保持 42 和 90 天，并根据其失重和厚度变化进行分析。然后在三个递增的载荷阶段进行循环加载。Ultrapro 网片的失重和厚度减少最大。该网片表现出 pH 不依赖特性。Surgipro 网片由于降解过程，具有 pH 不依赖的行为，只有轻微的失重和厚度减少。Dynamesh 的降解机制高度依赖于 pH，酸性环境作为降解催化剂。所有三种网片都观察到了力学滞后现象。Surgipro 中的变形较大（25%）；还观察到颈缩现象。Dynamesh 的变形为 22%，网片在施加的负载下散开，无法承受第三周期的循环负载。Ultrapro 网片的变形最小（10%）。尽管网片的组成和结构不同，但所有网片都发生了永久塑性变形，这将随着时间的推移降低网片的柔韧性。
