a Department of Cardiology, West China Hospital , Sichuan University , Chengdu , China.
Clin Exp Hypertens. 2018;40(4):337-343. doi: 10.1080/10641963.2017.1377217. Epub 2017 Sep 28.
Sleep disorders are known to increase the risk of hypertension, yet few studies have investigated the relation between sleep disorders and morning blood pressure (BP). This study aimed to determine, whether the morning BP is associated with sleep quality and sleep-disordered breathing. A total of 144 hypertensive patients were included in this cross-sectional study. Each subject underwent anthropometric measurements, biochemical testing, 24-h ambulatory BP monitoring, and polysomnography (PSG). Sleep quality and sleep-disordered breathing were determined by PSG parameters of sleep architecture and sleep respiratory. There were no significant differences between subjects with and without morning hypertension in the parameters of sleep architecture and sleep respiratory. In multiple regression analysis, morning BP was independently associated with night-time BP and morning BP surge, but not with the parameters of sleep architecture and sleep respiratory. Further analysis showed that both night-time BP and morning BP surge were independently associated with the sleep respiratory parameters. In conclusion, sleep-disordered breathing might indirectly affect the morning BP by elevated night-time BP, yet neither poor sleep quality nor sleep-disordered breathing was major determinants of elevated morning BP in hypertensive patients.
睡眠障碍已知会增加高血压的风险，但很少有研究调查睡眠障碍与晨血压（BP）之间的关系。本研究旨在确定晨血压是否与睡眠质量和睡眠呼吸障碍有关。共有 144 名高血压患者纳入本横断面研究。每位受试者均接受了人体测量、生化检测、24 小时动态血压监测和多导睡眠图（PSG）检查。睡眠质量和睡眠呼吸障碍通过 PSG 睡眠结构和睡眠呼吸参数来确定。在睡眠结构和睡眠呼吸参数方面，晨高血压患者与无晨高血压患者之间没有显著差异。多元回归分析显示，晨血压与夜间血压和晨血压飙升独立相关，而与睡眠结构和睡眠呼吸参数无关。进一步分析表明，夜间血压和晨血压飙升均与睡眠呼吸参数独立相关。总之，睡眠呼吸障碍可能通过升高的夜间血压间接影响晨血压，但在高血压患者中，睡眠质量差和睡眠呼吸障碍都不是晨血压升高的主要决定因素。
