Department of Internal Medicine, Occupational Diseases, Hypertension and Clinical Oncology, Wrocław Medical University, Wrocław, Poland.
Med Sci Monit. 2023 Sep 4;29:e941066. doi: 10.12659/MSM.941066.
Sleep research has garnered substantial interest among scientists owing to its correlation with various diseases, particularly elevated blood pressure observed in patients with obstructive sleep apnea. This systematic review aims to identify and analyze publications exploring the associations between sleep architecture and arterial hypertension. A comprehensive search of PubMed (MEDLINE), Scopus, and Embase databases yielded 111 reports, of which 7 manuscripts were included in the review. Four of the studies reported a significant reduction in the duration of the N3 phase of sleep in hypertensive patients, while 2 studies found a statistically significant reduction in the duration of the N2 and rapid eye movement (REM) stages of sleep. Three studies indicated increased sleep fragmentation in hypertensive patients. They showed a longer duration of the N1 stage of sleep, shorter duration of overall sleep time, and an increased apnea-hypopnea index in hypertensive patients. These findings underscore the association between the duration of non-REM/REM sleep stages and elevated BP, providing substantial evidence. Moreover, a notable increase in sleep fragmentation was observed among patients with hypertension. However, further research is warranted to expand and deepen our understanding of this intricate relationship. This systematic review serves as a valuable resource, guiding future investigations and contributing to advancements in the field of sleep and arterial hypertension.
睡眠研究在科学家中引起了极大的兴趣，因为它与各种疾病有关，特别是阻塞性睡眠呼吸暂停患者的血压升高。本系统评价旨在确定和分析探讨睡眠结构与动脉高血压之间关系的出版物。对 PubMed（MEDLINE）、Scopus 和 Embase 数据库进行全面检索，共获得 111 份报告，其中 7 份报告纳入本评价。四项研究报告高血压患者的 N3 期睡眠时间明显缩短，两项研究发现 N2 和快速眼动（REM）期睡眠时间的持续时间有统计学意义的减少。三项研究表明高血压患者的睡眠碎片化增加。他们显示高血压患者的 N1 期睡眠时间延长，总睡眠时间缩短，呼吸暂停-低通气指数增加。这些发现强调了非快速眼动/快速眼动睡眠阶段持续时间与血压升高之间的关联，提供了大量证据。此外，还观察到高血压患者的睡眠碎片化显著增加。然而，需要进一步的研究来扩大和深化我们对这种复杂关系的理解。本系统评价为未来的研究提供了有价值的资源，并为睡眠和动脉高血压领域的进展做出了贡献。
