Oyamada M, Dempo K, Fujimoto Y, Takahashi H, Satoh M I, Mori M, Masuda R, Yoshida M C, Satoh K, Sato K
Department of Pathology, Sapporo Medical College.
Jpn J Cancer Res. 1988 Jan;79(1):5-8. doi: 10.1111/j.1349-7006.1988.tb00002.x.
Spontaneous occurrence of placental glutathione S-transferase (GST-P)-positive foci was observed in the livers of 5-month-old LEC rats. Quantitative studies revealed that GST-P foci appeared after the onset of hepatitis. The number and size of GST-P foci increased with age and more foci were induced in males than in females. No sex difference, however, was found in the incidence of hepatitis. Although hepatitis is necessary for the induction of GST-P foci, it is insufficient for their further growth. Since hereditary hepatitis first appears at around 4 months of age, leading to a high incidence of hepatocellular carcinomas in later life, the spontaneous occurrence of the foci may be related to the development of hepatocellular carcinoma.
在5月龄的LEC大鼠肝脏中观察到胎盘谷胱甘肽S-转移酶（GST-P）阳性灶的自发出现。定量研究表明，GST-P阳性灶在肝炎发作后出现。GST-P阳性灶的数量和大小随年龄增加，雄性比雌性诱导出更多的阳性灶。然而，在肝炎发病率方面未发现性别差异。虽然肝炎是诱导GST-P阳性灶所必需的，但对于其进一步生长是不够的。由于遗传性肝炎最早在4个月左右出现，导致后期肝细胞癌的高发病率，这些阳性灶的自发出现可能与肝细胞癌的发生有关。
