Masuda R, Yoshida M C, Sasaki M, Dempo K, Mori M
Chromosome Research Unit, Faculty of Science, Hokkaido University, Sapporo.
Jpn J Cancer Res. 1988 Jul;79(7):828-35. doi: 10.1111/j.1349-7006.1988.tb00044.x.
A remarkably high incidence of hepatocellular carcinomas was observed in long-surviving LEC rats with hereditary hepatitis. Among the 60 LEC rats examined between 12 and 28 months of age from F29 and F30, 55 (92%) developed putative preneoplastic and neoplastic lesions such as hyperplastic foci and nodules, and hepatocellular carcinomas. Of these, hepatocellular carcinomas were observed with a high frequency (46/55; 84%). All rats of advanced age that survived more than 18 months developed hepatocellular carcinomas. These results suggest that the development of liver tumors in LEC rats is an age-associated phenomenon with serial hepatic alterations after the subsidence of acute hepatitis. The long-surviving rats had no normal tissue and showed chronic hepatitis in nontumorous tissues of the liver. Cholangiofibrosis was also found in most rats with hepatic lesions. Metastasis of hepatocellular carcinomas was found in four rats. Histologically, the hepatocellular carcinomas were of a well-differentiated type with a typical trabecular structure. Thus, LEC rats seem to be a promising animal model for studying the pathogenesis of hepatitis and hepatocellular carcinoma.
在患有遗传性肝炎的长期存活的LEC大鼠中，观察到肝细胞癌的发生率非常高。在对来自F29和F30的60只12至28月龄的LEC大鼠进行检查时，55只（92%）出现了推定的癌前和肿瘤性病变，如增生灶和结节以及肝细胞癌。其中，肝细胞癌的发生率很高（46/55；84%）。所有存活超过18个月的老龄大鼠都发生了肝细胞癌。这些结果表明，LEC大鼠肝脏肿瘤的发生是一种与年龄相关的现象，在急性肝炎消退后会出现一系列肝脏改变。长期存活的大鼠没有正常组织，肝脏非肿瘤组织显示慢性肝炎。在大多数有肝脏病变的大鼠中也发现了胆管纤维化。在4只大鼠中发现了肝细胞癌转移。从组织学上看，肝细胞癌为高分化型，具有典型的小梁结构。因此，LEC大鼠似乎是研究肝炎和肝细胞癌发病机制的一种很有前景的动物模型。
