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F-244 (1233A), a specific inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A synthase: taxonomy of producing strain, fermentation, isolation and biological properties.

作者信息

Tomoda H, Kumagai H, Takahashi Y, Tanaka Y, Iwai Y, Omura S

机构信息

Kitasato Institute, Kitasato University, Tokyo, Japan.

出版信息

J Antibiot (Tokyo). 1988 Feb;41(2):247-9. doi: 10.7164/antibiotics.41.247.

DOI:10.7164/antibiotics.41.247
PMID:2895759
Abstract
摘要

相似文献

1
F-244 (1233A), a specific inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A synthase: taxonomy of producing strain, fermentation, isolation and biological properties.F-244（1233A），3-羟基-3-甲基戊二酰辅酶A合酶的特异性抑制剂：产生菌的分类学、发酵、分离及生物学特性
J Antibiot (Tokyo). 1988 Feb;41(2):247-9. doi: 10.7164/antibiotics.41.247.
2
Potent inhibitory effect of antibiotic 1233A on cholesterol biosynthesis which specifically blocks 3-hydroxy-3-methylglutaryl coenzyme A synthase.抗生素1233A对胆固醇生物合成具有强效抑制作用，它能特异性阻断3-羟基-3-甲基戊二酰辅酶A合酶。
J Antibiot (Tokyo). 1987 Sep;40(9):1356-7. doi: 10.7164/antibiotics.40.1356.
3
Inhibition of 3-hydroxy-3-methylglutaryl coenzyme A synthase by antibiotic 1233A and other beta-lactones.抗生素1233A及其他β-内酰胺类化合物对3-羟基-3-甲基戊二酰辅酶A合酶的抑制作用。
Biochem Biophys Res Commun. 1990 Jun 15;169(2):610-6. doi: 10.1016/0006-291x(90)90374-v.
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Biosynthesis of antibiotic 1233A (F-244) and preparation of [14C]1233A.抗生素1233A（F-244）的生物合成及[14C]1233A的制备。
J Antibiot (Tokyo). 1992 Apr;45(4):563-7. doi: 10.7164/antibiotics.45.563.
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Synthesis and biological activity of new 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase inhibitors: 2-oxetanones with a side chain mimicking the folded structure of 1233A.新型3-羟基-3-甲基戊二酰辅酶A（HMG-CoA）合酶抑制剂的合成及生物活性：带有模拟1233A折叠结构侧链的2-氧杂环丁酮
Chem Pharm Bull (Tokyo). 1994 Mar;42(3):512-20. doi: 10.1248/cpb.42.512.
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Inhibition of hydroxymethylglutaryl-coenzyme A synthase by L-659,699.L-659,699对羟甲基戊二酰辅酶A合酶的抑制作用。
Proc Natl Acad Sci U S A. 1987 Nov;84(21):7488-92. doi: 10.1073/pnas.84.21.7488.
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Method of search for microbial inhibitors of mevalonate biosynthesis using animal cells.利用动物细胞寻找甲羟戊酸生物合成微生物抑制剂的方法。
J Antibiot (Tokyo). 1990 Apr;43(4):397-402. doi: 10.7164/antibiotics.43.397.
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F-244 specifically inhibits 3-hydroxy-3-methylglutaryl coenzyme A synthase.F - 244特异性抑制3 - 羟基 - 3 - 甲基戊二酰辅酶A合酶。
Biochim Biophys Acta. 1987 Dec 14;922(3):351-6.
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Synthesis of 1233A analogs and their inhibitory activity against hydroxymethylglutaryl coenzyme A synthase.1233A类似物的合成及其对羟甲基戊二酰辅酶A合酶的抑制活性。
J Antibiot (Tokyo). 1992 Jul;45(7):1139-47. doi: 10.7164/antibiotics.45.1139.
10
Inhibition of hepatic cholesterol biosynthesis by a 3-hydroxy-3-methylglutaryl coenzyme A synthase inhibitor, 1233A, in mice.3-羟基-3-甲基戊二酰辅酶A合酶抑制剂1233A对小鼠肝脏胆固醇生物合成的抑制作用。
Life Sci. 1993;52(19):1595-600. doi: 10.1016/0024-3205(93)90060-g.

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