State Key Laboratory Breeding Base of Marine Genetic Resources, Key Laboratory of Marine Genetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, 184 Daxue Road, Xiamen 361005, China.
Mar Drugs. 2019 Feb 20;17(2):125. doi: 10.3390/md17020125.
Five new (fusarisolins A⁻E, to ) and three known ( to ) polyketides were isolated from the marine-derived fungus H918, along with six known phenolics ( to ). Their structures were established by comprehensive spectroscopic data analyses, methoxyphenylacetic acid (MPA) method, chemical conversion, and by comparison with data reported in the literature. Compounds and are the first two naturally occurring 21 carbons polyketides featuring a rare β- and γ-lactone unit, respectively. All isolates ( to ) were evaluated for their inhibitory effects against tea pathogenic fungus and 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase gene expression. Compound showed potent antifungal activity with an ED value of 55 μM, while , , , and significantly inhibited HMG-CoA synthase gene expression.
从海洋来源真菌 H918 中分离得到了五个新的（fusarisolins A⁻E，to）和三个已知的（to）聚酮化合物，以及六个已知的酚类化合物（to）。通过综合光谱数据分析、甲氧基苯乙酸（MPA）法、化学转化以及与文献报道的数据进行比较，确定了它们的结构。化合物和是前两个天然存在的具有罕见β-和γ-内酯单元的 21 碳聚酮化合物。所有分离物（to）均评估了其对茶病原菌和 3-羟-3-甲基戊二酰辅酶 A（HMG-CoA）合酶基因表达的抑制作用。化合物表现出强烈的抗真菌活性，ED 值为 55 μM，而、、、和显著抑制了 HMG-CoA 合酶基因的表达。
Zotero 插件