Key Laboratory of Applied Chemistry and Nanotechnology at University of Jilin Province, Changchun University of Science and Technology, Changchun 130022, China.
Key Laboratory of Applied Chemistry and Nanotechnology at University of Jilin Province, Changchun University of Science and Technology, Changchun 130022, China.
J Colloid Interface Sci. 2018 Jan 15;510:292-301. doi: 10.1016/j.jcis.2017.09.085. Epub 2017 Sep 22.
Multifunctional nanocomposites (NCs) incorporating magnetic, luminescent and photothermal conversion properties are endowed with potential application in many fields such as imaging, tumor detection, drug delivery and therapy. Here, multifunctional MWCNTs-NaGdF:Yb, Er, Eu NCs, which offer the potential for integrated bioimaging and photothermal therapy (PTT) were fabricated by a facile hydrothermal method. The resulting sample exhibits uniform morphology, bright dual-modal luminescence and intrinsic paramagnetic properties. Under near-infrared laser excitation, NCs have excellent photothermal conversion properties. In addition, the MTT assay in HeLa cells shows that the NCs have good biocompatibility. Moreover, the up-conversion luminescence (UCL) imaging, X-ray computed tomography (CT) imaging and PTT in vitro of NCs were investigated. The results indicate that NCs can be used for dual-modal imaging-guided diagnose and PTT of cancer cells.
多功能纳米复合材料（NCs）具有磁性、发光和光热转换性能，有望在成像、肿瘤检测、药物输送和治疗等多个领域得到应用。在此，通过简便的水热法制备了多功能 MWCNTs-NaGdF:Yb，Er，Eu NCs，其具有集成生物成像和光热治疗（PTT）的潜力。所得样品具有均匀的形态、明亮的双模式发光和固有顺磁性。在近红外激光激发下，NCs 具有优异的光热转换性能。此外，HeLa 细胞的 MTT 试验表明，NCs 具有良好的生物相容性。此外，还研究了 NCs 的上转换发光（UCL）成像、X 射线计算机断层扫描（CT）成像和体外 PTT。结果表明，NCs 可用于癌细胞的双模式成像引导诊断和 PTT。
