Zhou Hengbo, Costello James C
Department of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Cancer Biology Program, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Department of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Cancer Biology Program, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Computational Bioscience Program University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Trends Cancer. 2017 Oct;3(10):673-675. doi: 10.1016/j.trecan.2017.08.005.
Identifying key factors that regulate the transition from primary to metastatic cancer is a fundamental challenge. Walsh et al. took a systems biology approach integrating computational, in vitro, and in vivo experiments to identify TRIM25 (tripartite motif containing 25) as a key factor that regulates metastatic gene signatures both at the transcriptional and post-transcriptional level in breast cancer. Targeting TRIM25 therapeutically is attractive because it governs a broad set of coordinated transcriptional modules that dictate metastatic progression.
确定调控原发性癌症向转移性癌症转变的关键因素是一项根本性挑战。沃尔什等人采用系统生物学方法，整合计算、体外和体内实验，以确定TRIM25（含三联基序蛋白25）是在转录和转录后水平调控乳腺癌转移基因特征的关键因素。从治疗角度靶向TRIM25很有吸引力，因为它控制着一系列广泛的协调转录模块，这些模块决定着转移进程。
