香叶木素通过减少DNA损伤和氧化应激来保护视网膜免受损伤。
Diosmetin protects against retinal injury via reduction of DNA damage and oxidative stress.
作者信息
Shen Zeren, Shao Jinjin, Dai Jiabin, Lin Yuchen, Yang Xiaochun, Ma Jian, He Qiaojun, Yang Bo, Yao Ke, Luo Peihua
机构信息
Institute of Pharmacology & Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, P.R. China.
Eye Center, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, P.R. China.
出版信息
Toxicol Rep. 2015 Dec 17;3:78-86. doi: 10.1016/j.toxrep.2015.12.004. eCollection 2016.
Visual impairment is a global public health problem that needs new candidate drugs. is a traditional Chinese drug, famous for its eye-protective function, with an unclear mechanism of action. To determine how contributes to vision, we identified, for the first time, the component of , diosmetin (DIO), which acts in protecting the injured retina in an adriamycin (ADR) improving model. We observed that DIO could attenuate the apoptosis of retinal cells in Sprague-Dawley rats and verified this effect in cultured human retinal pigment epithelium (RPE) cells, ARPE-19. Our further study on the mechanism revealed the counteractive effect of DIO on the attenuation of DNA damage and oxidative stress, which occurs in a wide range of retinal disorders. These results collectively promise the potential value of DIO as a retinal-protective agent for disorders that lead to blindness. In addition, we identified, for the first time, the component of , DIO, which acts in protecting the injured retina.
视力障碍是一个需要新型候选药物的全球性公共卫生问题。[药物名称]是一种传统中药，以其护眼功能而闻名，但其作用机制尚不清楚。为了确定[药物名称]如何对视力产生影响，我们首次鉴定出[药物名称]的成分香叶木素（DIO），它在阿霉素（ADR）改善模型中对受损视网膜具有保护作用。我们观察到DIO可以减轻Sprague-Dawley大鼠视网膜细胞的凋亡，并在培养的人视网膜色素上皮（RPE）细胞ARPE-19中证实了这一作用。我们对其机制的进一步研究揭示了DIO对DNA损伤和氧化应激减轻的对抗作用，而DNA损伤和氧化应激在多种视网膜疾病中都会发生。这些结果共同表明DIO作为一种用于导致失明的疾病的视网膜保护剂具有潜在价值。此外，我们首次鉴定出[药物名称]的成分DIO，它对受损视网膜具有保护作用。
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