将金头鲷暴露于受重金属污染的沉积物中会下调应激生物标志物的基因表达。
Exposure of the gilthead seabream () to sediments contaminated with heavy metals down-regulates the gene expression of stress biomarkers.
作者信息
Benhamed Said, Guardiola Francisco A, Martínez Salvadora, Martínez-Sánchez M J, Pérez-Sirvent Carmen, Mars Mohammed, Esteban María A
机构信息
Laboratory of Microbiology, Research Unity of biodiversity and valorisation of bioressources in arid zones, University of Gabes, Faculty of Sciences of Gabes, Tunisia.
Fish innate immune system group. Department of Cell Biology & Histology, Faculty of Biology. Regional Campus of International Excellence "Campus Mare Nostrum", University of Murcia, Spain.
出版信息
Toxicol Rep. 2016 Feb 26;3:364-372. doi: 10.1016/j.toxrep.2016.02.006. eCollection 2016.
Heavy metals incidence in the aquatic environment and its accumulation in fish are under constant review. Gilthead seabream () specimens were exposed for two weeks to sediments highly concentrated in metals, collected at the Portman Bay (Murcia, Spain). The metals bioaccumulation was tested in liver, muscle and skin. The potential of the sediment exposure to induce variation of the stress biomarkers genes was conducted in liver and skin. Results revealed that sediments were highly contaminated with metals. However, following 2 weeks exposure to the sediments, Cd accumulates only in liver. Interestingly, the expression of the genes and were significantly down-regulated in skin. Nevertheless, gene was up-regulated only in liver. Results uphold that the stress response magnitude was organ-dependent and the skin was the most responsive tissue to metal stress conditions. These results suggest that skin should be considered as target organ for biomarkers analysis in fishes.
水生环境中重金属的发生率及其在鱼类中的积累一直受到关注。将金头鲷（）样本暴露于在西班牙穆尔西亚的波特曼湾采集的高金属浓度沉积物中两周。在肝脏、肌肉和皮肤中测试了金属的生物积累情况。在肝脏和皮肤中研究了沉积物暴露诱导应激生物标志物基因变异的可能性。结果显示沉积物受到了高度金属污染。然而，在暴露于沉积物两周后，镉仅在肝脏中积累。有趣的是，基因和在皮肤中的表达显著下调。尽管如此，基因仅在肝脏中上调。结果表明应激反应程度具有器官依赖性，皮肤是对金属应激条件最敏感的组织。这些结果表明，皮肤应被视为鱼类生物标志物分析的靶器官。
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