Murbach Timothy S, Glávits Róbert, Hirka Gábor, Endres John R, Clewell Amy E, Szakonyiné Ilona Pasics
AIBMR Life Sciences, Inc., 2800 East Madison Street, Suite 202, Seattle, WA, 98112, USA.
Toxi-Coop Zrt., Magyar Jakobinusok tere 4/B, H-1122 Budapest, Hungary.
Toxicol Rep. 2017 Sep 12;4:494-501. doi: 10.1016/j.toxrep.2017.09.002. eCollection 2017.
Fernblock is a standardized commercial aqueous extraction of the leaves of the tropical fern promoted as an orally active photoprotective substance. In a previous battery of toxicological tests on Fernblock, no genotoxicy was observed and no oral toxicity was observed up to 1200 mg/kg bw/day. The current study was conducted in Hsd.Han Wistar rats using doses of 0, 2000, 3500, and 5000 mg/kg bw/day Fernblock by gavage for 28 consecutive days. No mortality or toxic effects were observed and no target organs were identified. The no observed adverse effect level was determined to be 5000 mg/kg bw/day, the highest dose tested.
Fernblock是一种标准化的热带蕨类植物叶的商业水提取物,被宣传为一种口服活性光保护物质。在之前对Fernblock进行的一系列毒理学测试中,未观察到遗传毒性,且在高达1200毫克/千克体重/天的剂量下未观察到口服毒性。本研究使用Hsd.Han Wistar大鼠,连续28天经口给予0、2000、3500和5000毫克/千克体重/天的Fernblock。未观察到死亡或毒性作用,也未确定靶器官。未观察到不良反应水平被确定为5000毫克/千克体重/天,即测试的最高剂量。